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  1. Gao Pan Jin Minmin Jiang Yujuan
    In: 北京周报:英文版 / Beijing Review, Jg. 60 (2017), Heft 31, S. 18
    Online academicJournal
    Siehe Detailanzeige für Volltext
  2. 段朋朋 禄忆秦 徐强
    In: 现代涂料与涂装 / Modern Paint and Finishing, 2013, Heft 2, S. 51
    academicJournal
  3. 刘小伟
    In: 现代财经:天津财经学院学报 / Modern Finance and Economics(Journal of Tianjin University of Finance and Economics), 2015, Heft 3, S. 99
    academicJournal
  4. 周洁
    In: 计算机与网络 / China Computer & Network, Jg. 41 (2015), Heft 10, S. 9
    academicJournal
  5. 陈向明
    In: 中国涂料 / China Paint, 2014, Heft 5, S. 42
    academicJournal
  6. 吴让君;唐万军;李晴红
    In: 涂层与防护 / Coatings Technology & Abstracts, Jg. 40 (2019), Heft 8, S. 55
    academicJournal
  7. 代楚楚
    In: 科技致富向导, 2012, Heft 29, S. 32
    academicJournal
  8. 李焱
    In: 投资北京 / Invest Beijing, 2013, Heft 12, S. 72
    academicJournal
  9. In: 投资北京 / Invest Beijing, 2017, Heft 2, S. 60
    academicJournal
  10. 王林涛
    In: 中国医学前沿杂志(电子版) / Chinese Journal of the Frontiers of Medical Science(Electronic Version), Jg. 10 (2018), Heft 3, S. 48
    academicJournal
  11. 杨磊 姚兰辉 安恒庆 王晓荣
    In: 中国全科医学 / Chinese General Practice, Jg. 19 (2016), Heft 12, S. 383
    academicJournal
  12. 马秀峰, 边春利
    In: 中国涂料 / China Paint, 2016, Heft 7, S. 61
    academicJournal
  13. 尹洪明 李小东 郭军
    In: 施工技术 / Construction Technology, Jg. 45 (2016), Heft 4, S. 127
    academicJournal
  14. 赵明久 彭昊 陈森 方洪松
    In: 生物骨科材料与临床研究 / Orthopaedic Biomechanics Materials and Clinical Study, Jg. 13 (2016), Heft 6, S. 58
    academicJournal
  15. 刘雯丽
    In: 表面技术 / Surface Technology, Jg. 42 (2013), Heft 1, S. 116
    academicJournal
  16. 刘畅 李枫 王莉 张侠
    In: 老年医学与保健 / Geriatrics & Health Care, Jg. 19 (2013), Heft 6, S. 374
    academicJournal
  17. BACKGROUND: Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 (HMGB1) is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS: Sixty rats were randomly divided into a normal control group (group A, n=10) anda Vibrio vulnificus sepsis group (group B, n=50). Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus (concentration 6×108 cfu/mL, volume 0.1 mL/100g)) into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance(ANOVA) and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS: Compared to group A (0.652±0.177), HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour (1.161±0.358, P=0.013), 24 hours (1.679±0.235, P=0.000),and 48 hours (1.258±0.274, P=0.004) (P〈0.05), and peaked at 24 hours. Compared to group A(0.594±0.190), HMGB1 protein expression at 6 hours (1.408±0.567, P=0.026) after infection wassignificantly increased (P〈0. 05), and peaked at 24 hours (2.415±1.064, P=0.000) after infection.Compared to group A (0.699±0.054), lung water content was significantly increased at 6 hours(0.759±0.030, P=0.001),12 hours (0.767±0.023, P=0.000), 24 hours (0.771±0.043, P=0.000) and 48hours (0.789±0.137, P=0.000) after infection (P〈0.05). Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION: Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis.
    Qiao-meng Qiu;Zhong-wang Li;Lu-ming Tang;Qi Sun;Zhong-qiu Lu;Huan Liang;Guang-liang Hong;Meng-fang Li
    In: 世界急诊医学杂志(英文), Jg. 2 (2011), Heft 4, S. 302
    Online academicJournal
  18. 韩文骥
    In: 工业安全与环保 / Industrial Safety and Environmental Protection, 2013, Heft 8
    academicJournal
  19. 夏光涛 张源潮 付敏 武森森
    In: 中华风湿病学杂志 / Chinese Journal of Rheumatology, Jg. 17 (2013), Heft 3, S. 186
    academicJournal
  20. In: 投资北京 / Invest Beijing, 2004, Heft 6, S. 58
    academicJournal
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