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  1. Rui Zhong (659088) ; Xin Jiang (6348) ; et al.
    2021
    academicJournal
  2. Gao, Bingqiang ; Zhou, Dongkai ; et al.
    In: Frontiers in Endocrinology ; volume 12 ; ISSN 1664-2392, 2021
    academicJournal
  3. Bahruddin ; Fadhillah, Ivan ; et al.
    In: Journal of Physics: Conference Series ; volume 1655, issue 1, page 012091 ; ISSN 1742-6588 1742-6596, 2020
    academicJournal
  4. Ahad, Nor Azwin ; Ahmad, Sahrim Hj
    In: IOP Conference Series: Materials Science and Engineering ; volume 701, issue 1, page 012017 ; ISSN 1757-8981 1757-899X, 2019
    academicJournal
  5. 2023
    unknown
  6. 2023
    unknown
  7. Has, Ioan ; Miclaus, Simona ; et al.
    In: Journal of Modern Physics ; volume 10, issue 09, page 1090-1124 ; ISSN 2153-1196 2153-120X, 2019
    academicJournal
  8. Hussein, Mohamad Saed ; Teh, Pei Leng ; et al.
    In: AIP Conference Proceedings ; INTERNATIONAL SYMPOSIUM ON ADVANCED MATERIALS AND PROCESSING 2021 (ISAMP 2021) ; ISSN 0094-243X, 2022
    Konferenz
  9. Jaafar, C. N. ; Aiza ; et al.
    2021
    academicJournal
  10. Shahdan, Dalila ; Flaifel, Moayad Husein ; et al.
    2019
    academicJournal
  11. Martsenko, Nataliia
    In: osteuropa recht ; volume 65, issue 2, page 223-237 ; ISSN 0030-6444, 2019
    academicJournal
  12. 2020
    unknown
  13. Ruf, Mohd Farid Hakim Mohd ; Ahmad, Sahrim ; et al.
    In: AIP Conference Proceedings ; ISSN 0094-243X, 2018
    Konferenz
  14. Ahmad, Ishak ; Latif, Norliza A ; et al.
    In: Polymer Journal ; volume 37, issue 11, page 866-869 ; ISSN 0032-3896 1349-0540, 2005
    academicJournal
  15. Figure 1. SEA-like domains cooperate with adjacent domains to behave as proteolytic switches. ; (A) Schematic of Synthetic Notch Assay for Proteolytic Switches (SNAPS). Cells co-expressing Flag-Notch-X-Gal4 chimeras, where X is a putative proteolysis region of another receptor, and luciferase reporter constructs are co-cultured with DLL4 ligand-expressing cells to induce Notch activation and expression of luciferase. (B) Schematic of chimeric constructs utilized in the signaling assay. Protein domains are color coded and labeled below. Amino acid ranges used for each construct are in parentheses under the names. Note that Notch's SEA-like domain is also referred to as the Heterodimerization Domain (HD) in the literature. Abbreviations used: Cad: cadherin. EGF: Epidermal growth factor. LBD: Ligand binding domain. LNR: Lin-12 Notch-like repeats. ND: N-terminal domain. PKD: polycystic kidney disease domain. S/T rich: serine-threonine rich. TFP: Teal fluorescent protein. TM: transmembrane domain. TY: thyroglobulin type-1A domain. (C) Luciferase reporter gene activity profile of Notch and Notch chimera constructs (1 ng transfected in 96wp) co-cultured with MS5 cells or MS5 cells stably expressing DLL4. BB-94 = Batimastat (pan-metalloproteinase inhibitor) GSI = Compound E (γ-secretase inhibitor). Data shown are triplicate measurements from a representative experiment. Error bars represent the SEM of triplicate measurements. (D) Cell surface ELISA of Notch and Notch chimera constructs. Anti-Flag primary and goat anti-mouse HRP secondary antibodies were used to detect cell surface expression levels of each chimera. The horizontal dotted line corresponds to Notch expression levels. Error bars represent the SEM of triplicate measurements. (E) Structures and PDB IDs of SEA-like domains (gray) with applicable adjacent domains (purple). The Notch adjacent domain is comprised of three cysteine-rich, calcium binding Lin12 Notch repeats. Protocad15 (De-la-Torre et al., 2019; Dionne et al., 2018; Ge et al., 2018) has an Ig-like adjacent domain and EpCAM (Pavšič et al., 2014) has a cysteine-rich thyroglobulin adjacent domain. The buried surface area of the adjacent domains are 3800, 1300, and 2800 square Angstroms for Notch, Protocad15, and EpCAM, respectively. SEA-like domains were structurally aligned to the Notch SEA-like domain.
    2019
    unknown
  16. Bulut, Tangul ; Ayse Arducoglu Merter ; et al.
    In: International Journal of Research - Granthaalayah 7(10) 269-279, 2019
    academicJournal
  17. Suyu Wang (4729044) ; Yue Yu (260119) ; et al.
    2021
    academicJournal
  18. Powell, Arfon ; Wheat, Jenni ; et al.
    2015
    academicJournal
  19. Wheat, Jenni ; Powell, Arfon ; et al.
    2015
    academicJournal
  20. Comai, Giorgio
    2017
    unknown
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