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602 Treffer

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  1. Detailansicht für Treffer 1 öffnen
    T-Rex vs TMX cartoon
    Kelsall, Emily
    In: Being a Therapist in a Time of Climate Breakdown ; page 11-13 ; ISBN 9781003436096; (2024)
    Buch
    Wie komme ich dran?
  2. Detailansicht für Treffer 2 öffnen
    Characterization of TMX transmembrane protein in Bacillus subtilis and its effects on antibiotic resistance, membrane permeability, and membrane fluidity
    Zaver, Henna
    In: Chancellor’s Honors Program Projects, 2020
    Online academicJournal
    Zugriff:
    Volltext
    Wie komme ich dran?
  3. Detailansicht für Treffer 3 öffnen
    Looking for new thermoelectric materials among the TMX intermetallics using high-throughput calculations
    Barreteau, Celine ; Crivello, Jean-Claude ; et al.
    2018
    academicJournal
    Wie komme ich dran?
  4. Detailansicht für Treffer 4 öffnen
    Characterizing TMX and chemotactic receptor arrays through bacterial two-hybrid and beta-galactosidase assays
    Hubler, Adam Keith
    In: Chancellor’s Honors Program Projects, 2017
    Online academicJournal
    Zugriff:
    Volltext
    Wie komme ich dran?
  5. Detailansicht für Treffer 5 öffnen
    Characterizing TMX and chemotactic receptor arrays through bacterial two-hybrid and beta-galactosidase assays
    Hubler, Adam Keith
    In: Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology, 2017
    Online academicJournal
    Zugriff:
    Volltext
    Wie komme ich dran?
  6. Detailansicht für Treffer 6 öffnen
    Figure 2: FTIR spectra of TMX, PCL-P, and PCL-TMX electrospun nanofibers.
    2021
    unknown
    Wie komme ich dran?
  7. Detailansicht für Treffer 7 öffnen
    Figure 3: XRD patterns of (A) TMX, (B) PCL-P, (C) PCL-TMX.
    2021
    unknown
    Wie komme ich dran?
  8. Detailansicht für Treffer 8 öffnen
    Phase diagrams of Ba(Fe(1-x)TMx)2As2 (TM = Rh, Pd) single crystals
    Ni, N. ; Thaler, A. ; et al.
    2009
    academicJournal
    Wie komme ich dran?
  9. Detailansicht für Treffer 9 öffnen
    Electrochemical Sensing of Neonicotinoids Using Laser-Induced Graphene
    Zachary T. Johnson (11251372) ; Kelli Williams (3556088) ; et al.
    2021
    academicJournal
    Wie komme ich dran?
  10. Detailansicht für Treffer 10 öffnen
    Figure 3. Specific TGFBR2 ablation in retinal microglia induces abnormalities in microglial density, distribution, and morphology. ; (A) TG animals administered tamoxifen (TMX) 3 weeks prior, relative to wild type (WT) mice and control mice, demonstrated that TGFBR2 ablation resulted in increased microglial numbers and decreased ramification in the OPL. Scale bar = 100 µm. (B) Analysis of CD11b+ microglia numbers in each animal (two retinas combined) using flow-cytometry showed a significant increase in microglial numbers in TG vs. control animals at 3- and 10 weeks post-TMX. Manual counts of Iba1 +microglia numbers (C) and proliferating Ki67+, Iba1 +microglia (D) in retinal flat-mounts from animals 4 weeks post-TMX demonstrated increases at the levels of the IPL, OPL, and subretinal space (SRS) in TG vs. control retina. (E) TGFBR2-ablated microglia 4 weeks post-TMX showed reduced process ramification and decreased dendritic area (as highlighted in outlines of individual microglial dendritic arbors). TGFBR2-ablated microglia demonstrated branched morphologies (example shown in yellow box, expanded in inset) that showed close adherent contact with IB4-labelled (red) retinal vessels (arrows indicating points of contact). Scale bar = 100 µm. Morphological analysis of individual microglia showed significant decreases in the number of branch points (F) and in the areas of individual arbors (G) of microglia in both IPL and OPL in TGFBR2-ablated microglia. Despite having increased numbers of total microglia, TMX-treated TG retinas have a greater proportion of retinal area not directly occupied by microglial processes (H, areas highlighted in blue), indicating decreased microglial coverage. Graphical data are presented as means ± SEM; p values are from unpaired t-test with Welch’s correction, data points in (C), (D), and (H) represent four individual imaging fields from three animals in each group, those in (F) and (G) represent 16 individual microglia cells from four animals in each group).
    2019
    unknown
    Wie komme ich dran?
  12. Detailansicht für Treffer 12 öffnen
    Figure 6. TGFBR2 ablation in retinal microglia induces Müller cell gliosis in the retina. ; (A) Immunohistochemical analysis demonstrates upregulation of immunopositivity to GFAP 3 weeks post-TMX in TG animals relative to control animals. GFAP immunopositivity was localized to glutamine synthetase (GS)-labeled Müller cell processes, indicating the induction of Müller cell gliosis. Scale bar = 50 µm. (B) qPCR analysis of retinas isolated from control and TG animals 2 and 8 weeks post-TMX demonstrates a significant upregulation of GFAP mRNA expression following TGFBR2 ablation in retinal microglia. Graphical data are presented as means ± SEM; p values are from one-way analysis of variance (ANOVA) and Sidak’s multiple comparison test, n = 3 animals of mixed sex in each group.(C) RT-PCR analysis of retinal expression of genes associated with A1- and A2-specific astrocytic gliosis following microglial TGFBR2 ablation found progressive upregulation of A1-associated transcripts relative to control, while A2-associated transcripts were relatively unchanged (numbers indicate means, *, **, *** indicate p values < 0.05,
    2019
    unknown
    Wie komme ich dran?
  13. Detailansicht für Treffer 13 öffnen
    Figure 9. TGFBR2 ablation in retinal microglia increases pathological choroidal neovascularization (CNV) in an in vivo laser injury model. ; (A) In vivo evaluation for abnormalities in retinal vascular permeability using fluorescein angiography was performed in control and TG mice 12 weeks following tamoxifen (TMX) administration beginning at the age of 2 months. No abnormal leakage or vascular structure were detected. (B) Immunohistochemical analysis of endothelial cells (labeled with IB4 and an antibody to CD31) and retinal pericytes (labeled with an antibody to NG2) in retinal vasculature showed normal morphologies and distributions following TGFBR2 ablation in TG mice 12 weeks post-TMX. Scale bar = 100 µm. (C) Control and TG mice 3 weeks post-TMX were subjected to in vivo laser injury in a model of CNV formation. CNV complexes were analyzed in RPE flat-mounts using immunohistochemistry 7 days after laser injury and compared. Scale bar = 200 µm. TGFBR2-ablated TG animals demonstrated a higher recruitment of Iba1+ myeloid cells to the laser injury site (D), which was correlated with a larger laser lesion size (as labeled with phalloidin) (E) and a larger CNV area (F). (p values are from unpaired t-tests with Welch’s correction, data points are from 40 lesions from six animals in each group).
    2019
    unknown
    Wie komme ich dran?
  15. Detailansicht für Treffer 15 öffnen
    Figure 4. Constitutive expression of microglial ‘sensome’ genes are downregulated upon TGFBR2 ablation in retinal microglia. ; (A) Retinal microglia from control and TG mice were isolated by flow-cytometry 2 weeks following tamoxifen (TMX) administration and mRNA levels of microglial ‘sensome’ genes compared using qPCR. mRNA levels of Cx3cr1, P2yr12, Tmem119, and Siglech were all significantly decreased in microglia from TG vs. control mice. (B) Microglia from the retinas of WT mice were cultured and exposed to media containing TGFB1 (10 or 20 ng/ml), or TGFB2 (10 ng/ml) (media containing 10 ng/ml of BSA served as a control), and mRNA levels of microglial ‘sensome’ genes compared following 24 hr of exposure. mRNA levels of Tmem119 and Siglech were increased by TGFBR2 ligands (TGFB1 or TGFB2), indicating positive regulation of microglial ‘sensome’ genes via TGFBR2-mediated signaling. (C, D) As TG animals contained an IRES-EYFP cassette 3’ to CreERT recombinase in the Cx3cr1 locus, EYFP expression, as regulated by the Cx3cr1 promoter, could be constitutively detected in IBA1-immunopositive retinal microglia in control animals. In TG animals at 3 weeks post-TMX, Cx3cr1-driven EYFP fluorescence was diminished in Iba1+ microglia, indicating downregulation of Cx3cr1 promoter activity. (E, G) Immunohistochemical analysis of TMEM119 showed strong colocalization with Iba1 in microglia of control animals but decreased immunopositivity in TGFBR2-ablated microglia in TG animals. Scale bars = 100 µm. Graphical data in (A), (B), (D) and (F) are presented as means ± SEM; p values in (A), (D), and (F) are from multiple t-tests, while that in (B) are from 2-way ANOVA analysis with Sidak’s multiple comparisons test, * indicate p
    2019
    unknown
    Wie komme ich dran?
  18. Detailansicht für Treffer 18 öffnen
    Figure 2. Gill stem cells located at the periphery of branchial arches generate more filaments life-long. ; (A) Scheme showing the expected outcome assuming a progenitor (left bottom) or a stem cell (right bottom) model. Please note that the schemes considered as ‘labelled’ any filament containing EGFP+ cells all along their longitudinal axis. (B) Entire gill from a double transgenic GaudíUbiq.iCre GaudíRSG fish 2 month after induction with TMX. (C) Branchial arch from a double transgenic GaudíUbiq.iCre GaudíRSG fish 2 months after induction with TMX. Arrowheads in B and C indicate recombined embryonic filaments located at the centre of branchial arches, and asterisks indicate stretches of peripheral filaments with the same recombination status. Note that the present resolution does not allow revealing different recombination patterns in each filament. (D) Graphs showing the distribution of switches in stretches of the six most peripheral filaments. The graphs show a comparison of the experimental data (black) to the expected distribution according to a progenitor model (light gray, left) and to a stem cell model (gray, right). Scale bar is 500 µm in (C).
    2019
    unknown
    Wie komme ich dran?
  19. Detailansicht für Treffer 19 öffnen
    Figure 7. TGFBR2 ablation in retinal microglia induces degenerative changes in the retina. ; (A, B) In vivo evaluation of retinal structure by optical coherence tomography (OCT) in control animals and in TG animals 3 and 10 weeks following tamoxifen (TMX)-administration showed a preserved lamination in TG animals (insets at higher magnification in yellow boxes) but a progressive and significant reduction in the total retinal thickness relative to controls. Scale bar = 300 µm. Significant reductions in overall thickness were contributed to by reductions in both the inner (measured from vitreal surface to the outer plexiform layer) and the outer retinal layers (measured from the outer plexiform layer to the apical surface of the RPE layer) (p values are from 1-way ANOVA analysis with Tukey’s multiple comparisons test, data points are from 6 eyes of 3 animals). (C, D) Histological analysis of retinal lamina thicknesses in paraffin-embedded sections show significant decreases in the thickness of the inner plexiform layer (IPL), inner nuclear layer (ONL), outer plexiform layer (OPL), and outer nuclear layer (ONL) in TG animals 3 weeks post-TMX relative to controls (p values are from unpaired t-tests with Welch’s correction, data points are from 3 sections from four animals). Scale bar = 50 µm. (E, F) Evaluation for apoptotic retinal cells using TUNEL labeling demonstrated the emergence of apoptotic cells in both the INL and ONL in TG retinas 10 weeks post-TMX. (p values are from unpaired t-tests with Welch’s correction, data points are from 3 sections from four animals). Scale bar = 50 µm. (G, H) Comparison of electroretinographic (ERG) responses between control vs. TG animals 10 weeks post-TMX demonstrated in dark-adapted responses (G) a small but significant decrease in a-wave amplitude and a marked decrease in b-wave amplitudes in TG animals. Light-adapted responses (H) were similar for a-wave amplitude but significantly decreased in b-wave amplitude. The b-to-a amplitude ratios were significantly decreased in TG animals in both dark- and light-adapted responses for a range of flash intensities (p values are from 2-way ANOVA analysis, data points are both eyes of 8 control and 8 TG animals).
    2019
    unknown
    Wie komme ich dran?
  20. Detailansicht für Treffer 20 öffnen
    Figure 2. Specific TGFBR2 ablation in retinal microglia induces rapid and progressive changes in microglial morphology and distribution. ; The time course of morphological changes in retinal microglia following tamoxifen (TMX)-induced ablation of TGFBR2 expression was followed using immunohistochemical analysis in retinal flat-mounts. Panels show changes at the level of the OPL; microglia were labeled using an antibody to IBA1 and retinal vessels labeled with IB4. Gliotic changes in radial Müller glia processes were marked using an antibody to GFAP. At 1 day following TMX administration, a slight reduction in ramification in microglia processes was observed. From 2–5 days post-TMX, a further decrease in microglial ramification and an increase in microglia numbers were detected. From 3–10 weeks post-TMX, retinal microglia transitioned to a branched morphology, demonstrating a close fasciculation with the retinal vasculature. GFAP immunopositivity in Müller glia was prominently upregulated at this time. Scale bar = 100 µm.
    2019
    unknown
    Wie komme ich dran?
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