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  1. Lai, Ngoc Minh
    2022
    academicJournal
  2. Dipti ; Borovik Jr., A. ; et al.
    2020
    academicJournal
  3. Lai, Ngoc
    In: Proceedings of the 16th International Workshop on Semantic Evaluation (SemEval-2022, 2022
    Konferenz
  4. Shrivastava, Mayank ; Mathur, Pooja ; et al.
    In: Journal of the Indian Academy of Geriatrics ; ISSN 0974-3405 0974-2484, 2018
    academicJournal
  5. Nelles, Oliver
    In: Nonlinear System Identification ; page 1151-1163 ; ISBN 9783030474386 9783030474393; (2020)
    Buch
  6. Solomon Ahmed Mohammed (10196674) ; Mesfin Haile Kahissay (11610734) ; et al.
    2021
    Bild
  7. Botz, M.
    2020
    Online Hochschulschrift
  8. Kern, Helmut ; Stramare, Roberto ; et al.
    2010
    academicJournal
  9. Ralchenko, Yu. ; Gillaspy, J. D.
    2013
    academicJournal
  10. Taehoon Kim (79056) ; Daesik Kim (162386) ; et al.
    2021
    academicJournal
  11. Zanato, Riccardo ; Martino, Leonora ; et al.
    2010
    academicJournal
  12. Li, S. ; Koulentianos, D. ; et al.
    2023
    unknown
  13. Li, S. ; Koulentianos, D. ; et al.
    2023
    unknown
  14. Mallick, Arijit ; Liang, Hanfeng ; et al.
    2020
    Online unknown
  15. Mizuguchi, J. Mizuguchi*
    In: Zeitschrift für Kristallographie - New Crystal Structures ; volume 218, issue JG, page 139-140 ; ISSN 2197-4578 1433-7266, 2003
    academicJournal
  16. Mizuguchi, J.
    In: Zeitschrift für Kristallographie - New Crystal Structures ; volume 218, issue 1, page 137-138 ; ISSN 2197-4578 1433-7266, 2003
    academicJournal
  17. Mizuguchi, J.
    In: Zeitschrift für Kristallographie - New Crystal Structures ; volume 218, issue 1, page 139-140 ; ISSN 2197-4578 1433-7266, 2003
    academicJournal
  18. Figure 5. Both DP and SP differentiation trajectories approach the transcriptional state of primary MNs (pMNs), but DP does so with higher precision. ; (a) tSNE visualization of 874 single cell transciptomes from FACS purified Mnx1+ MNs from embryos reveals heterogeneity within this population. To make comparisons between DP and SP with pMNs we used only the subset of Mnx1:GFP+ primary cells in a bona-fide MN state. See Figure 5—figure supplement 1 for marker gene expression in each population. (b) Comparison of average gene expression profiles for cell states along the DP and SP trajectories with pMNs. In both methods similarity increases as differentiation proceeds. Late DP states are the most similar to embryonic MNs. (c) Projection of the reference E13.5 pMNs into the visualization from Figure 3 revealed that pMNs closely associate with the terminal states of both DP and SP (i). Close examination of the terminal populations (EMN, LMN) from DP and SP compared to pMNs reveals heterogeneity representing state subtypes (ii). At a single cell level DP LMNs were the most closely associated with E13.5 pMNs; 64% of DP LMNs had at least 1 pMN nearest neighbor out of its most similar 50 cells compared to 6% for SP LMNs (iii). The subtypes present within terminal DP and SP populations could be annotated using marker genes. DP and SP EMNs express progenitor genes including Mnx1, along with Nkx2-2 and Nkx6-1 in SP only. The major SP LMN outgroup expressed Gata3, indicating a hindbrain identity. Both DP LMNs and pMNs shared expression of the terminal MN differentiation gene Ebf2. (d) Systematic pairwise differential gene expression analysis between terminal DP and SP states and pMNs. Each panel is a volcano plot of differentially expressed transcription factors. Both DP and SP LMNs show limited gene expression differences to pMNs. The dominant differences are positional, with DP and SP LMNs lacking the most posterior Hox genes. Other expression differences are explained by differences in terminal state subtypes as shown in c). Differentially expressed genes were filtered for TFs with a corrected p-value 4, and minimum expression of 1umi/cell average.
    2017
    unknown
  19. 2017
    unknown
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