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116 Treffer

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  1. Detailansicht für Treffer 1 öffnen
    Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK)
    Giamas, Georgios ; Spencer, John
    2022
    academicJournal
    Wie komme ich dran?
  2. Detailansicht für Treffer 2 öffnen
    Linear Intransitive Temporal Logic of Knowledge LTK_r, Decision Algorithms, Inference Rules
    Lukyanchuk, Alexandra ; Rybakov, Vladimir
    2014
    academicJournal
    Wie komme ich dran?
  3. Detailansicht für Treffer 3 öffnen
    Weather Forecasting Using Local Traditional Knowledge (LTK) in the Midst of Climate Change in Domboshawa, Zimbabwe
    Tanyanyiwa, Vincent Itai
    In: Climate Change Management ; Handbook of Climate Change Communication: Vol. 2 ; page 1-20 ; ISSN 1610-2002 1610-2010 ; ISBN 9783319700656 9783319700663; (2017)
    Buch
    Wie komme ich dran?
  4. Detailansicht für Treffer 4 öffnen
    Figure 5. In-cell RTK activity profiling with BCR-ABL and EGFR inhibitors. ; (A) Activity of BCR-ABL inhibitors ponatinib (Pona.), imatinib (Ima.), dasatinib (Dasa.), bosutinib (Bosu.), and nilotinib (Nilo.) against 28 wild-type RTKs, evaluated in 293T cells transfected with RTKs and treated with inhibitors for 20–24 hr. The panel compiles data from immunoblot detections of activated RTKs, each treated with inhibitor concentrations derived from the experiments shown in Figure 5—figure supplement 1. Only one concentration is shown for nilotinib due to its cell toxicity at higher concentrations. Asterisks highlight the previously unreported nilotinib targets LTK and INSR (Supplementary file 1E; Figure 5—figure supplement 1). (B) Activity profiling of 30 wild-type (wt) RTKs and 116 of their active mutants in the presence of 0.5 µM osimertinib. 293T cells were transfected with RTK vectors together with pKrox24(2xD-E_inD)Luc24 hr before osimertinib treatment (for 24 hr). The colors reflect the osimertinib-mediated inhibition of pKrox24(2xD-E_inD)Luctrans-activation induced by a given RTK, relative to cells untreated with osimertinib. Basal levels of osimetrinib-mediated inhibition of pKrox24(2xD-E_inD)Luc were obtained from cells transfected with empty plasmid and then subtracted from the data. (C) 293T cells were transfected with wt LTK or its mutants, and treated with osimertinib (Osi.) for 24 hr. The LTK autophosphorylation (p) reflect LTK activity. Total LTK and actin serve as loading controls. (D) Cell-free kinase assays were carried out with recombinant LTK or EGFR and osimertinib added to the kinase reaction. Phosphorylation (p) of a recombinant STAT1 and autophosphorylation was used to detect LTK and EGFR activation, respectively. Samples with omitted ATP serve as negative controls for kinase activity.
    2017
    unknown
    Wie komme ich dran?
  5. Detailansicht für Treffer 5 öffnen
    Unification and Inference Rules in the Multi-modal Logic of Knowledge and Linear Time LTK
    Башмаков, С. И. ; Институт математики и фундаментальной информатики ; et al.
    2016
    Online academicJournal
    Zugriff:
    Full Text Finder (Volltext)
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  6. Detailansicht für Treffer 6 öffnen
    Unification and Inference Rules in the Multi-modal Logic of Knowledge and Linear Time LTK
    Башмаков, С. И. ; Институт математики и фундаментальной информатики ; et al.
    2016
    Online academicJournal
    Zugriff:
    Full Text Finder (Volltext)
    Wie komme ich dran?
  7. Detailansicht für Treffer 7 öffnen
    Figure 5—figure supplement 1. Analyses of cytotoxicity and kinase activities of BCR-ABL and EGFR inhibitors. ; (A) 293T cells were treated with ponatinib, imatinib, dasatinib, bosutinib, nilotinib and osimertinib for 24 hr and the cell amounts were determined by cell counting. Data represent average from three independent experiments (two biological replicates for each point in every experiment) with indicated SD. 0, cells treated with TKI vehicle DMSO. With exception of dasatinib, the inhibitors did not affect 293T proliferation at the concentration ranges (red lines) used in RTK screening (Figure 5A). (B, C) Cells were transfected with human wild-type ABL, and p190 and p210 variants of BCR-ABL, and wild-type human EGFR or its activating mutant T790M, treated with inhibitors for 24 hr and analyzed for activating phosphorylation (p) by immunoblot. Actin and total levels of expressed kinases serve as loading controls. Cells transfected with empty plasmid serve as transfection control. (D) Evidence demonstrating that 2 and 5 μM nilotinib inhibits expression of transfected FGFR2, MET and RON. (E) Inhibition of LTK and INSR autophosphorylation by nilotinib. (B–E) Data show a representative experiment for three independent experiments.
    2017
    unknown
    Wie komme ich dran?
  8. Detailansicht für Treffer 8 öffnen
    Leukocyte Receptor Tyrosine Kinase interacts with secreted midkine to promote survival of migrating neural crest cells
    Vieceli, Felipe Monteleone ; Bronner, Marianne E.
    In: Development, 145(20), Art. No. dev164046, (2018-10-24, 2018
    academicJournal
    Wie komme ich dran?
  9. Detailansicht für Treffer 9 öffnen
    Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial
    Hankey, GJ ; Hackett, ML ; et al.
    In: urn:ISSN:1474-4422 ; urn:ISSN:1474-4465 ; The Lancet Neurology, 19, 8, 651-660, 2020
    Online academicJournal
    Zugriff:
    Volltext
    Wie komme ich dran?
  10. Detailansicht für Treffer 10 öffnen
    Figure 1—figure supplement 2. Conservation of phosphoepitopes in the intracellelular domains of ALK and LTK. ; (A) Schematic overview of anaplastic lymphoma kinase (ALK) and leukocyte tyrosine kinase (LTK) protein domain structure. (B) Alignment of the intracellular region of ALK and LTK, highlighting in yellow the Y1278 phosphoepitope in the activation loop which shares significant homology between ALK and LTK, and the Y1604 phosphoepitope of ALK which is not found in LTK.
    2015
    unknown
    Wie komme ich dran?
  11. Detailansicht für Treffer 11 öffnen
    Figure 4—figure supplement 3. ALK and LTK interact in the presence of FAM150A. FAM150A and anaplastic lymphoma kinase (ALK) coimmunoprecipitate with leukocyte tyrosine kinase (LTK). ; Immunoprecipitation with either anti-IgG control or anti-HA (LTK) was performed and the resulting immonoprecipitates immunoblotted for the presence of ALK (mAb135), LTK (HA) and FAM150A. *indicates immunoglobulin light and heavy chains.
    2015
    unknown
    Wie komme ich dran?
  12. Detailansicht für Treffer 12 öffnen
    Linear Intransitive Temporal Logic of Knowledge LTK_r, Decision Algorithms, Inference Rules
    Lukyanchuk, Alexandra ; Rybakov, Vladimir
    2014
    academicJournal
    Wie komme ich dran?
  13. Detailansicht für Treffer 13 öffnen
    ensembler_dataset-models-LTK-RON
    Parton, Daniel L. ; Grinaway, Patrick B. ; et al.
    2016
    Online unknown
    Zugriff:
    Volltext
    Wie komme ich dran?
  14. Detailansicht für Treffer 14 öffnen
    Downingtown Area School District v. Chester County Board of Assessment Appeals v. LTK Associates LP
    Commonwealth Court of Pennsylvania
    In: 2015, 2015
    academicJournal
    Wie komme ich dran?
  15. Detailansicht für Treffer 15 öffnen
    НЕКОТОРЫЕ СВОЙСТВА ЛИНЕЙНОЙ ЛОГИКИ ЗНАНИЯ И ВРЕМЕНИ LTK
    Лукьянчук, А. Н.
    In: VIII Всероссийская конференция «Молодёжь и наука», Секция «Современные проблемы математики и компьютерных наук», 2012
    Konferenz
    Wie komme ich dran?
  16. Detailansicht für Treffer 16 öffnen
    НЕКОТОРЫЕ СВОЙСТВА ЛИНЕЙНОЙ ЛОГИКИ ЗНАНИЯ И ВРЕМЕНИ LTK
    Лукьянчук, А. Н.
    In: VIII Всероссийская конференция «Молодёжь и наука», Секция «Современные проблемы математики и компьютерных наук», 2012
    Konferenz
    Wie komme ich dran?
  17. Detailansicht für Treffer 17 öffnen
    {10} Leyde, UB, Ltk. 1819
    In: Album Christine de Pizan ; Texte, Codex & Contexte ; page 309-310 ; ISSN 2294-8333 2294-8341; (2012)
    Buch
    Wie komme ich dran?
  18. Detailansicht für Treffer 18 öffnen
    Figure 4—figure supplement 1. FAM150A binds to the extracellular domain of human ALK by ELISA. ; Purified FAM150A was coated on plates and binding of extracellular domain of ALK (ALK-ECD-Fc) was detected by anti-Fc HRP conjugate. LTK-ECD-Fc was used as a binding positive control. FAM150A binds specifically to the ECD of human ALK.
    2015
    unknown
    Wie komme ich dran?
  19. Detailansicht für Treffer 19 öffnen
    Portable Common Lisp graphical user interfaces with LTk
    Herth, Peter
    In: Proceedings of the 2007 International Lisp Conference, 2007
    Konferenz
    Wie komme ich dran?
  20. Detailansicht für Treffer 20 öffnen
    Laser Thermokeratoplasty and Wavefront-Guided LTK
    Mian, Shahzad
    In: Hyperopia and Presbyopia ; page 83-94; (2003)
    Buch
    Wie komme ich dran?
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