Synthesis of Innovative Series of MIPs using Acrylic Acid and Diallyl Dimethylammonium Chloride for Adsorption and Environmental Assessment of Chlordiazepoxide.
In: Journal of Polymers & the Environment, Jg. 31 (2023-10-01), Heft 10, S. 4533-4545
Online
academicJournal
Zugriff:
Removal of pharmaceutical compounds from waste waters is important issue in environmental science and technology. Drugs represent an environmental worry because of their existence in ecosystems, leading to ecotoxicological concern. Development of new methods that are both highly selective and effective to extract and analysis of pharmaceutical compounds in complicated matrices are great interest and urgently needed in nvironmental science, pharmaceutical industry, and biomedicine. In this study, three types of molecularly imprinted polymers (MIPs) were prepared and applied for the selective separation of chlordiazepoxide from ethanol as a solvent. The engineered MIPs were synthesized through the bulk polymerization of acrylic acid and diallyl dimethylammonium chloride as monomers in the presence of chlordiazepoxide as a template. N, N'-methylene bisacrylamide and azobisisobutyronitrile (AIBN) were applied as cross-linker and initiator, respectively. The prepared MIPs were characterized by Fourier transform infrared spectroscopy (FT-IR), Adsorption/desorption analysis (BET-BJH), Field emission scanning electron microscopy (FE-SEM), Energy dispersive X-ray spectroscopy (EDX), and Thermal gravimetric analysis (TGA) techniques. Also, the performance of constructed MIPs was compared with non-imprinted polymer (NIP) or template-free polymers. The obtained results shown that the prepared MIP (M2) in the presence of acrylic acid, diallyl dimethylammonium chloride and chlordiazepoxide as a template shows excellent specific extraction ability for chlordiazepoxide drug in comparison with NIP. The optimum amount of MIP, pH, and volume of solvent for drug separation were 0.02 g, pH = 7, and 5 mL of ethanol at room temperature, respectively. It is concluded that, drug extraction using MIPs can successfully substitute conventional removal procedures due to the multiple advantages of these advanced materials like low cost, reusability, easy performance, excellent selectivity, and good stability. Consequently, candidate MIPs could be an alternative for the determination of these types of contaminants (pharmaceutical compounds) in complex environmental samples. Based on obtained results, this type of polymeric materials opens new horizon for the efficient environmental analysis in pharmaceutical industry in near future. [ABSTRACT FROM AUTHOR]
Titel: |
Synthesis of Innovative Series of MIPs using Acrylic Acid and Diallyl Dimethylammonium Chloride for Adsorption and Environmental Assessment of Chlordiazepoxide.
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Autor/in / Beteiligte Person: | Anvari, Mahsa ; Shadjou, Nasrin ; Mahmoudian, Mehdi |
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Zeitschrift: | Journal of Polymers & the Environment, Jg. 31 (2023-10-01), Heft 10, S. 4533-4545 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1566-2543 (print) |
DOI: | 10.1007/s10924-023-02880-4 |
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