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Total Effective Xenoestrogen Burden in Serum Samples and Risk of Endometrial Cancer in the Spanish Screenwide Case-Control Study.
In: Environmental Health Perspectives, Jg. 132 (2024-02-01), Heft 2, S. 27012-1- (13S.)
Online
academicJournal
Zugriff:
BACKGROUND: Endometrial cancer is a hormone-dependent cancer, and estrogens play a relevant role in its etiology. However, little is known about the effects of environmental pollutants that act as xenoestrogens or that influence estrogenic activity through different pathways. OBJECTIVE: We aimed to assess the relationship between the combined estrogenic activity of mixtures of xenoestrogens present in serum samples and the risk of endometrial cancer in the Screenwide case–control study. METHODS: The total effective xenoestrogen burden (TEXB) attributable to organohalogenated compounds (TEXB-a) and to endogenous hormones and more polar xenoestrogens (TEXB-ß) was assessed in serum from 156 patients with endometrial cancer (cases) and 150 controls by combining chemical extraction and separation by high-performance liquid chromatography with the E-SCREEN bioassay for estrogenicity. RESULTS: Median TEXB-a and TEXB-ß levels for cases (0.30 and 1.25 Eeq pM/mL, respectively) and controls (0.42 and 1.28 Eeq pM/mL, respectively) did not significantly differ (??=0.653 and 0.933, respectively). An inverted-U risk trend across serum TEXB-a and TEXB-ß levels was observed in multivariate adjusted models: Positive associations were observed for the second category of exposure in comparison to the lowest category of exposure [odds ratio (OR) = 2.11 (95% CI: 1.13, 3.94) for TEXB-a, and OR=3.32 (95% CI: 1.62, 6.81) for TEXB-ß], whereas no significant associations were observed between the third category of exposure and the first [OR = 1.22 (95% CI: 0.64, 2.31) for TEXB-a, and OR=1.58 (95% CI: 0.75, 3.33) for TEXB-ß]. In mutually adjusted models for TEXB-a and TEXB-ß levels, the association of TEXB-a with endometrial cancer risk was attenuated [OR=1.45 (95% CI: 0.61, 3.47) for the second category of exposure], as well as estimates for TEXB-ß (OR=2.68; 95% CI: 1.03, 6.99). Most of the individual halogenated contaminants showed no associations with both TEXB and endometrial cancer. CONCLUSIONS: We evaluated serum total xenoestrogen burden in relation to endometrial cancer risk and found an inverted-U risk trend across increasing categories of exposure. The use of in vitro bioassays with human samples may lead to a paradigm shift in the way we understand the negative impact of chemical mixtures on human health effects. These results are relevant from a public health perspective and for decision-makers in charge of controlling the production and distribution of chemicals with xenoestrogenic activity. [ABSTRACT FROM AUTHOR]
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Total Effective Xenoestrogen Burden in Serum Samples and Risk of Endometrial Cancer in the Spanish Screenwide Case-Control Study.
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Autor/in / Beteiligte Person: | Costas, Laura ; Frias-Gomez, Jon ; Peinado, Francisco M. ; Manuel Molina-Molina, Jose ; Peremiquel-Trillas, Paula ; Paytubi, Sonia ; Crous-Bou, Marta ; de Francisco, Javier ; Caño, Victor ; Benavente, Yolanda ; Pelegrina, Beatriz ; Manuel Martínez, José ; Pineda, Marta ; Brunet, Joan ; Matias-Guiu, Xavier ; de Sanjosé, Silvia ; Ponce, Jordi ; Olea, Nicolás ; Alemany, Laia ; Fernández, Mariana F. |
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Zeitschrift: | Environmental Health Perspectives, Jg. 132 (2024-02-01), Heft 2, S. 27012-1- (13S.) |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/EHP13202 |
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