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Aflatoxin Exposure May Contribute to Chronic Hepatomegaly in Kenyan School Children.
In: Environmental Health Perspectives, Jg. 120 (2012-06-01), Heft 6, S. 893-896
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Zugriff:
Background: Presentation with a firm type of chronic hepatomegaly of multifactorial etiology is common among school-age children in sub-Saharan Africa. Objective: Aflatoxin is a liver toxin and carcinogen contaminating staple maize food. In this study we examined its role in chronic hepatomegaly. Methods: Plasma samples collected in 2002 and again in 2004 from 218 children attending two schools in neighboring villages were assayed for aflatoxin exposure using the aflatoxin-albumin adduct (AF-alb) biomarker. Data were previously examined for associations among hepatomegaly, malaria, and schistosomiasis.Results: AF-alb levels were high in children from both schools, but the geometric mean (95% confidence interval) in year 2002 was significantly higher in Matangini [206.5 (175.5, 243.0) pg/mg albumin] than in Yumbuni [73.2 (61.6, 87.0) pg/mg; p < 0.001]. AF-alb levels also were higher in children with firm hepatomegaly [176.6 (129.6, 240.7) pg/mg] than in normal children [79.9 (49.6, 128.7) pg/mg; p = 0.029]. After adjusting for Schistosoma mansoni and Plasmodium infection, we estimated a significant 43% increase in the prevalence of hepatomegaly/hepatosplenomegaly for every natural-log-unit increase in AF-alb. In 2004, AF-alb levels were markedly higher than in 2002 [539.7 (463.3, 628.7) vs. 114.5 (99.7, 131.4) pg/mg; p < 0.001] but with no significant difference between the villages or between hepatomegaly and normal groups [539.7 (436.7, 666.9) vs. 512.6 (297.3, 883.8) pg/mg], possibly because acute exposures during an aflatoxicosis outbreak in 2004 may have masked any potential underlying relationship. Conclusions: Exposure to aflatoxin was associated with childhood chronic hepatomegaly in 2002. These preliminary data suggest an additional health risk that may be related to aflatoxin exposure in children, a hypothesis that merits further testing. [ABSTRACT FROM AUTHOR]
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Aflatoxin Exposure May Contribute to Chronic Hepatomegaly in Kenyan School Children.
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Autor/in / Beteiligte Person: | Gong, Yun Yun ; Wilson, Shona ; Mwatha, Joseph K. ; Routledge, Michael N. ; Castelino, Jovita M. ; Zhao, Bin ; Kimani, Gachuhi ; Kariuki, H. Curtis ; Vennervald, Birgitte J. ; Dunne, David W. ; Wild, Christopher P. |
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Zeitschrift: | Environmental Health Perspectives, Jg. 120 (2012-06-01), Heft 6, S. 893-896 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/ehp.1104357 |
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