PCDD/F and PCB concentrations in sera from the Canadian Health Measures Survey (CHMS) from 2007 to 2009

Abstract: In order to establish a national baseline estimate of the concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in Canadians, pooling of individual human sera was performed to ensure that a high frequency of detectable concentrations of analytes would be achieved. Nearly 5000 (4583) sera samples from Cycle 1 of the Canadian Health Measures Survey (CHMS) collected between 2007 and 2009 were used to form 59 composite pools of approximately 25mL each. Pools were categorized by sex and age with participants ranging from 6 to 79years. The pooled samples were analysed for 17 PCDD/Fs and 36 PCB congeners, and from these data, total toxic equivalent concentrations (TEQ2005 PCDD/F+Dioxin-like [DL]-PCB) were estimated. The average 2,3,7,8 tetrachlorodibenzodioxin (TCDD) concentration was <1pgg−1 on a lipid extractable basis. The average total TEQ2005 PCDD/F+DL-PCB was 11pgTEQg−1 lipid and average ΣPCB concentrations were about 100ngg−1 lipid. Sex did not affect the concentrations, while PCB and PCDD/F concentrations were positively correlated with age (p<0.001). It appeared in some cases that the age group 6–11years had higher concentrations of these persistent organic pollutants (POPs) than the concentrations observed in 12–19year olds, however, the results were not statistically significant based on pair-wise comparisons. Concentration levels and patterns observed in this study of Canadians were similar to those reported in the US and European populations. [Copyright &y& Elsevier]