Electron-Deficient Olefin Ligands Enable Generation of Quaternary Carbons by Ni-Catalyzed Cross-Coupling.
In: Journal of the American Chemical Society, Jg. 137 (2015-05-06), Heft 17, S. 5638-5641
academicJournal
Zugriff:
A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable β-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and chemoselectivity for C-C bond formation over β-H elimination. This ligand is easy to access, is stable, and presents a modular framework for reaction discovery and optimization. We expect that these attributes, combined with the fact that the ligands impart distinct electronic properties to a metal, will support the invention of new transformations not previously possible using established ligands. [ABSTRACT FROM AUTHOR]
Titel: |
Electron-Deficient Olefin Ligands Enable Generation of Quaternary Carbons by Ni-Catalyzed Cross-Coupling.
|
---|---|
Autor/in / Beteiligte Person: | Chung-Yang (Dennis) Huang ; Doyle, Abigail G. |
Link: | |
Zeitschrift: | Journal of the American Chemical Society, Jg. 137 (2015-05-06), Heft 17, S. 5638-5641 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0002-7863 (print) |
DOI: | 10.1021/jacs.5b02503 |
Schlagwort: |
|
Sonstiges: |
|