Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.
In: General & Comparative Endocrinology, Jg. 216 (2015-05-15), S. 86-89
academicJournal
Zugriff:
Fibroblast growth factor (FGF)-21 is secreted from the liver, pancreas, and adipose in response to prolonged fasting/starvation to facilitate lipid and glucose metabolism. Northern elephant seals naturally fast for several months, maintaining a relatively elevated metabolic rate to satisfy their energetic requirements. Thus, to better understand the impact of prolonged food deprivation on FGF21-associated changes, we analyzed the expression of FGF21, FGF receptor-1 (FGFR1), β-klotho (KLB; a co-activator of FGFR) in adipose, and plasma FGF21, glucose and 3-hydroxybutyrate in fasted elephant seal pups. Expression of FGFR1 and KLB mRNA decreased 98% and 43%, respectively, with fasting duration. While the 80% decrease in mean adipose FGF21 mRNA expression with fasting did not reach statistical significance, it paralleled the 39% decrease in plasma FGF21 concentrations suggesting that FGF21 is suppressed with fasting in elephant seals. Data demonstrate an atypical response of FGF21 to prolonged fasting in a mammal suggesting that FGF21-mediated mechanisms have evolved differentially in elephant seals. Furthermore, the typical fasting-induced, FGF21-mediated actions such as the inhibition of lipolysis in adipose may not be required in elephant seals as part of a naturally adapted mechanism to support their unique metabolic demands during prolonged fasting. [ABSTRACT FROM AUTHOR]
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Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.
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Autor/in / Beteiligte Person: | Suzuki, Miwa ; Lee, Andrew Y. ; Vázquez-Medina, José Pablo ; Viscarra, Jose A. ; Crocker, Daniel E. ; Ortiz, Rudy M. |
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Zeitschrift: | General & Comparative Endocrinology, Jg. 216 (2015-05-15), S. 86-89 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0016-6480 (print) |
DOI: | 10.1016/j.ygcen.2015.03.009 |
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