Clonal dissemination of linezolid-resistant Staphylococcus capitis with G2603T mutation in domain V of the 23S rRNA and the cfr gene at a tertiary care hospital in China
In: BMC Infectious Diseases, Jg. 15 (2015-03-01), Heft 1, S. 97-102
Online
academicJournal
Zugriff:
Background: The present study aims to investigate the potential mechanism of linezolid-resistant Staphylococcus capitis (LRSC) isolates collected from our hospital. Methods: The susceptibilities of 5 Staphylococcus capitis isolates displaying resistance towards linezolid were determined by E-test. Polymerase chain reactions (PCRs) and DNA sequencing were used to investigate the potential molecular mechanism. Clonal relatedness between these strains was analyzed by pulsed-field gel electrophoresis (PFGE). Results: The MICs of linezolid on these 5 isolates were >256 μg/mL. The G2603T mutation was observed in the domain V of the 23S rRNA with cfr gene being also widely detected among these 5 strains. PFGE analysis displayed close genetic relatedness between these linezolid-resistant isolates. Conclusions: The emergence of LRSC isolates carrying G2603T mutation in the domain V of the 23S rRNA and harboring cfr gene in our hospital may pose a potential challenge to the public health. [ABSTRACT FROM AUTHOR]
Titel: |
Clonal dissemination of linezolid-resistant Staphylococcus capitis with G2603T mutation in domain V of the 23S rRNA and the cfr gene at a tertiary care hospital in China
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Autor/in / Beteiligte Person: | Zhou, Wanqing ; Niu, Dongmei ; Cao, Xiaoli ; Ning, Mingzhe ; Zhang, Zhifeng ; Shen, Han ; Zhang, Kui |
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Zeitschrift: | BMC Infectious Diseases, Jg. 15 (2015-03-01), Heft 1, S. 97-102 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 1471-2334 (print) |
DOI: | 10.1186/s12879-015-0841-z |
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