The effect of rilonacept versus placebo on health-related quality of life in patients with poorly controlled familial Mediterranean fever.
In: BioMed Research International, Jg. 2014 (2014), S. 854842-854842
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Zugriff:
Objective: To examine the effect of rilonacept on the health-related quality of life (HRQoL) in patients with poorly controlled familial Mediterranean fever (FMF). Methods: As part of a randomized, double-blinded trial comparing rilonacept and placebo for the treatment of FMF, patients/parents completed the modified Child Health Questionnaire (CHQ) at baseline, and at the start and end of each of 4 treatment courses, 2 each with rilonacept and placebo. Results: Fourteen subjects were randomized; mean age was 24.4 ± 11.8 years. At baseline the physical HRQoL score was significantly less (24.2 ± 49.5) but the psychosocial score was similar to the population norm (49.5 ± 10.0). There were significant improvements in most HRQoL concepts after rilonacept but not placebo. Significant differences between rilonacept and placebo were found in the physical (33.7 ± 16.4 versus 23.7 ± 14.5, P = 0.021) but not psychosocial scores (51.4 ± 10.3 versus 49.8 ± 12.4, P = 0.42). The physical HRQoL was significantly impacted by the treatment effect and patient global assessment. Conclusion: Treatment with rilonacept had a beneficial effect on the physical HRQoL in patients with poorly controlled FMF and was also significantly related to the patient global assessment. This trial is registered with ClinicalTrials.gov Identifier NCT00582907. [ABSTRACT FROM AUTHOR]
Titel: |
The effect of rilonacept versus placebo on health-related quality of life in patients with poorly controlled familial Mediterranean fever.
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Autor/in / Beteiligte Person: | Hashkes, Philip J ; Spalding, Steven J ; Hajj-Ali, Rula ; Giannini, Edward H ; Johnson, Anne ; Barron, Karyl S ; Weisman, Michael H ; Pashinian, Noune ; Reiff, Andreas O ; Samuels, Jonathan ; Wright, Dowain ; Lovell, Daniel J ; Huang, Bin |
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Zeitschrift: | BioMed Research International, Jg. 2014 (2014), S. 854842-854842 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 2314-6133 (print) |
DOI: | 10.1155/2014/854842 |
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