Experimental ureteral obstruction and knockout animals
In: Archives de Pédiatrie, Jg. 10 (2003-10-01), Heft 10, S. 903-910
academicJournal
Zugriff:
Obstructive uropathies caused by congenital malformations of the urinary tract are relatively frequent in newborn. These obstructive lesions are the main cause for renal disease in infancy. Most of these uropathies are treated by surgical interventions restoring the drainage function of the urinary tract. Clinically these patients are cured but the question remains wether these patients will develop renal disease in adult life, since it has been recently shown in animal models that transient, neonatal and prenatal, ureteral obstruction induces significant renal deterioration later in life. Except for angiotensin converting enzyme inhibitors that slow down the progression of renal disease, no specific drugs reducing renal fibrosis exist. Animal models of ureteral obstruction have allowed to clearly identify the events leading to tubulointerstitial fibrosis. Furthermore, more recently, the use of ureteral obstruction in genetically engineered animals has shown pro– and anti-fibrotic properties of a large number of molecules. These studies using genetically engineered animals have suggested several new future promising therapeutic directions to treat renal fibrosis. [Copyright &y& Elsevier]
Fre´quentes chez l’enfant, les uropathies obstructives sont principalement dues a` des malformations conge´nitales du tractus urinaire. Ces pathologies obstructives sont une des principales causes d’insuffisance re´nale chez l’enfant. Le traitement des uropathies obstructives repose en grande partie sur la chirurgie, permettant ainsi le re´tablissement d’un bon drainage du rein. Suite a` cet acte chirurgical, la majorite´ des patients est alors conside´re´e comme cliniquement gue´rie. Cependant, chez l’animal, les obstructions ure´te´rales corrige´es montrent l’apparition progressive d’une fibrose tubulo-interstitielle re´nale. A` l’heure actuelle, il n’existe pas de traitement spe´cifique permettant de faire re´gresser cette fibrose. Seul les inhibiteurs de l’enzyme de conversion semblent ralentir sa progression et maintenir la fonction re´nale. Graˆce aux mode`les animaux d’obstruction ure´te´rale, il a e´te´ possible de reproduire les diffe´rentes e´tapes conduisant a` la fibrose tubulo-interstitielle re´nale. Un bon nombre des me´canismes cellulaires et mole´culaires ont pu ainsi eˆtre de´crits. Plus re´cemment, l’apparition d’animaux ge´ne´tiquement modifie´s a permis de pre´ciser le roˆle be´ne´fique ou de´le´te`re de certaines mole´cules implique´es dans le de´veloppement de la fibrose. Les re´sultats re´cents obtenus chez l’animal laissent entrevoir des pistes the´rapeutiques « antifibrosantes » prometteuses. [Copyright 2003 Elsevier]
Titel: |
Experimental ureteral obstruction and knockout animals
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Autor/in / Beteiligte Person: | Schanstra, J. ; Bascands, J.L. |
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Zeitschrift: | Archives de Pédiatrie, Jg. 10 (2003-10-01), Heft 10, S. 903-910 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 0929-693X (print) |
DOI: | 10.1016/S0929-693X(03)00398-1 |
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