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In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers.
In: Artificial Cells, Nanomedicine & Biotechnology, Jg. 44 (2016-05-01), Heft 3, S. 898-902
Online
academicJournal
Zugriff:
In this report, the oligosaccharides of hyaluronan (oHA)-histidine-menthone 1,2-glycerol ketal (MGK) (oHM) carried pH-sensitive MGK as hydrophobic moieties and oHA as the target of the CD44 receptor. The oHM could self-assemble, with a diameter of 65 nm. The cellular uptake, indicated by the fluorescent signals, was higher at 4 h. Theex vivoimaging indicated that micelles have a longer blood circulation, beyond 5 h. The fluorescence intensity of the micelles in the liver and spleen was much higher from 5 to 24 h. The CD44 receptor-targeting, indicated by the fluorescence signals of A549 and MDA-MB-231 group, were higher than those of the HepG2 and the control. [ABSTRACT FROM AUTHOR]
Titel: |
In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers.
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Autor/in / Beteiligte Person: | Chen, Daquan ; Sun, Jingfang ; Sun, Kaoxiang ; Liu, Wanhui ; Wu, Zimei |
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Zeitschrift: | Artificial Cells, Nanomedicine & Biotechnology, Jg. 44 (2016-05-01), Heft 3, S. 898-902 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 2169-1401 (print) |
DOI: | 10.3109/21691401.2014.998828 |
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