Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins.
In: eLife, 2017-03-01, S. 1-26
Online
academicJournal
Zugriff:
Most bacteria are in fierce competition with other species for limited nutrients. Some bacteria can kill nearby cells by secreting bacteriocins, a diverse group of proteinaceous antimicrobials. However, bacteriocins are typically freely diffusible, and so of little value to planktonic cells in aqueous environments. Here, we identify an atypical two-protein bacteriocin in the a-proteobacterium Caulobacter crescentus that is retained on the surface of producer cells where it mediates cell contact-dependent killing. The bacteriocin-like proteins CdzC and CdzD harbor glycine-zipper motifs, often found in amyloids, and CdzC forms large, insoluble aggregates on the surface of producer cells. These aggregates can drive contact-dependent killing of other organisms, or Caulobacter cells not producing the CdzI immunity protein. The Cdz system uses a type I secretion system and is unrelated to previously described contact-dependent inhibition systems. However, Cdz-like systems are found in many bacteria, suggesting that this form of contact-dependent inhibition is common. [ABSTRACT FROM AUTHOR]
Titel: |
Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins.
|
---|---|
Autor/in / Beteiligte Person: | García-Bayona, Leonor ; Guo, Monica S. ; Laub, Michael T. |
Link: | |
Zeitschrift: | eLife, 2017-03-01, S. 1-26 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 2050-084X (print) |
DOI: | 10.7554/eLife.24869 |
Schlagwort: |
|
Sonstiges: |
|