Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots.
In: Journal of Nanobiotechnology, Jg. 15 (2017-09-05), Heft 1, S. 1-8
Online
academicJournal
Zugriff:
Background: Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet-visible, and fluorescence spectroscopy. Then, we assessed the anti-hemorrhagic effects and related hemostatic mechanisms of the obtained PTC-CQDs. Results: The PTC-CQDs separated from PTC are spherical, monodisperse, and have a narrow size distribution between 2 and 8 nm. In the pharmacology experiment, remarkable anti-hemorrhage effects of PTC-CQDs were revealed. Additionally, the rats showed a profound decrease in activated partial thromboplastin time and increase in fibrinogen and PLT after PTC-CQDs treatment. Conclusions: These results indicated the explicit hemostasis effect of PTC-CQDs, which not only provided a new idea for the material research of PTC, but have also provided new insights into potential biomedical and healthcare applications of CQDs in the field of haemorrhage control and laid a solid foundation for future drug discovery. [ABSTRACT FROM AUTHOR]
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Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots.
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Autor/in / Beteiligte Person: | Yan, Xin ; Zhao, Yan ; Luo, Juan ; Xiong, Wei ; Liu, Xiaoman ; Cheng, Jinjun ; Wang, Yongzhi ; Zhang, Meiling ; Qu, Huihua |
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Zeitschrift: | Journal of Nanobiotechnology, Jg. 15 (2017-09-05), Heft 1, S. 1-8 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1477-3155 (print) |
DOI: | 10.1186/s12951-017-0296-z |
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