糖皮质激素联合免疫球蛋白治疗机械通气的吉兰巴雷综合征的 临床疗效分析

Objective: To analyze the clinical efficacy of corticosteroids combined with IYIG for Guillain-Baire Syndrome treated by mechanical ventilation. Methods: The clinical data of patients with Guillain-Bane Syndrome treated by mechanical ventilation from six hospitals in xi'an from January 2008 to July 2016 were retrospectively analyzed and followed up. the efficacy which was compared between IYIG and corticosteroids combined with IYIG treatment. Results: The efficacy between IYIG treatment group and corticosteroids combination IYIG treatment group showed no significant difference in the improvement rate of MRC sum-score and HFGS score, mortality, mechanical ventilation time, hospital time, time in ICU. the MRC sum-score and HFGS score at discharge and at 6 months and incidence of complications. Conclusions: For patients with Guillain-Bane Syndrome treated by mechanical ventilation, the short-time (discharge) and longer-time (6 months after discharge) clinical efficacy and security of corticosteroids combined with IYIG treatment was equal to corticosteroids alone. [ABSTRACT FROM AUTHOR]

目的：分析糖皮质激素联合免疫球蛋白治疗需要机械通气的吉兰巴雷综合征的临床疗效。方法：回顾性分析2008 年1 月至 2016 年7 月西安市六家医院收治的采用机械通气的吉兰巴雷综合征患者的临床资料，并对其进行随访，比较单用免疫球蛋白与 糖皮质激素联合免疫球蛋白的疗效差异。结果：两组在出院时及出院后6 个月的总有效率(MRC 及HFGS的改善率)、死亡率、机 械通气时间、住院时间、在ICU住院时间、出院时及出院后6 个月的MRC总得分和HFGS 得分以及并发症发生率比较差异均无 统计学意义(P>0.05)。结论：对于机械通气的吉兰巴雷综合征患者，在使用免疫球蛋白的基础上增加糖皮质激素的使用，对其短期 ( 出院时) 及较长期( 出院后6 个月)的临床疗效和安全性均无显著影响。 [ABSTRACT FROM AUTHOR]