MiR-155 inhibits transformation of macrophages into foam cells via regulating CEH expression.
In: Biomedicine & Pharmacotherapy, Jg. 104 (2018-08-01), S. 645-651
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Zugriff:
MiR-155 can inhibit the formation of atherosclerosis by interfering with the transformation of macrophages into foam cells that plays a critical role in the pathogenesis of atherosclerosis, but the precise mechanisms of miR-155 are still unknown. Herein, we observed that mRNA and protein expression levels of CEH were significantly upregulated in a dose- and time-dependent manner by transfected with miR-155 mimics in THP-1 macrophages. Further studies showed that overexpression of miR-155 can significantly inhibit foam cells formation, reduce intracellular CE accumulation and enhance the efflux of FC and cholesterol, result in a decrease of intracellular lipid accumulation; while this effect was significantly reversed by siCEH. Meanwhile, we found that Tim-3 is associated with miR-155-mediated CEH expression in THP-1 macrophage-derived foam cells. Overexpression of Tim-3 can attenuate miR-155-mediated CEH induction. Taken together, our findings demonstrated that miR-155 can inhibit the transformation of macrophages into foam cells by enhancing CEH signaling pathway in macrophages, this effect is likely to be achieved by inhibiting the expression of Tim-3. [ABSTRACT FROM AUTHOR]
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MiR-155 inhibits transformation of macrophages into foam cells via regulating CEH expression.
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Autor/in / Beteiligte Person: | Zhang, Fengxiang ; Zhao, Jinsong ; Sun, Dapeng ; Wei, Ning |
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Zeitschrift: | Biomedicine & Pharmacotherapy, Jg. 104 (2018-08-01), S. 645-651 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0753-3322 (print) |
DOI: | 10.1016/j.biopha.2018.05.068 |
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