Oral deferiprone administration ameliorates cisplatin‐induced nephrotoxicity in rats.
In: Journal of Pharmacy & Pharmacology, Jg. 70 (2018-10-01), Heft 10, S. 1357-1368
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Zugriff:
Abstract: Objectives: Cisplatin is one of the widely used antitumour agents with major clinical side effect, nephrotoxicity. We showed the role of iron in cisplatin‐induced nephrotoxicity that entrance to the cell via transferrin receptor (TfR) as a gatekeeper for iron uptake. We also examined the effect of iron chelator deferiprone against this toxicity. Methods: Thirty male Wistar rats were randomly divided into six groups. Group I (saline orally for 10 days); group II (saline orally for 10 days plus single injection of cisplatin 7 mg/kg, intraperitoneally on 5th day); groups III, IV and V (deferiprone 50, 100 and 200 mg/kg orally for 10 days, respectively, plus cisplatin on 5th day). Group VI (deferiprone, orally). Results: Deferiprone provided functional and significant histological‐proven protection in group IV. Deferiprone attenuated the increased creatinine, BUN, malondialdehyde and iron concentrations in cisplatin‐injected animals. The increased amounts of TfR and decreased levels of HIF‐1α and related anti‐apoptotic genes expression in cisplatin‐treated animals were improved by deferiprone. Conclusions: The results supported a role for iron in cisplatin‐induced nephrotoxicity and TfR may serve as an important source of iron. Based on these findings, deferiprone pretreatment may play a role in preventing cisplatin‐induced nephropathy in cancer patient. [ABSTRACT FROM AUTHOR]
Titel: |
Oral deferiprone administration ameliorates cisplatin‐induced nephrotoxicity in rats.
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Autor/in / Beteiligte Person: | Makhdoumi, Pouran ; Abnous, Khalil ; Mehri, Soghra ; Etemad, Leila ; Imenshahidi, Mohsen ; Karimi, Gholamreza |
Zeitschrift: | Journal of Pharmacy & Pharmacology, Jg. 70 (2018-10-01), Heft 10, S. 1357-1368 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0022-3573 (print) |
DOI: | 10.1111/jphp.12990 |
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