丹参注射液与丹参多酚酸盐注射液对不稳定型心绞痛患者冠状动脉 微循环的影响

Objective: To compare the effect of Danshen injection and Salvia miltiorrhiza injection on the coronary microcirculation in patients with unstable angina pectoris (UA). Methods: 105 cases of patients with UA from May 2014 to May 2017 were randomly divided into the Salvia miltiorrhiza group (n=50) and the Salvia miltiorrhiza polyphenol salt group (n=55). the Salvia miltiorrhiza group was given intravenous drip of Salvia miltiorrhiza injection 20 mL before PCI, 1 time d, in total 3 d; and the Salvia miltiorrhiza polyphenol salt group was given intravenous drip Salvia miltiorrhiza polyphenol salt injection 200 ing.l timed, in total 3 d. The coronary flow reserve (CFR). coronary microcirculation resistance coefficient (1MR) and TIMI blood flow classification were measured before and immediately after PCI. Results: The CFR, IMR and TIMI flow grade of both groups were significantly improved compared with preoperation(P < 0.05). and the IMR of Salvia miltiorrhiza group was significantly lower than mat of the Salvianolate group (P<0.05), while the CFR. TIMI flow grade of two groups showed no significant difference (P>0.05). Conclusions: Danshen injection and Salvia miltiorrhiza injection could significantly improve the coronary microcirculation in patients with UA, and the injection of Salvia miltiorrhiza Bunge was better man Danshen injection. [ABSTRACT FROM AUTHOR]

比较丹参注射液与丹参多酚酸盐注射液对不稳定型心绞痛(UA)患者冠状动脉微循环的影响。方法:将2014 年5 月～ 2017 年5 月105 例UA患者随机分为丹参组(n=50)与丹参多酚酸盐组(n=55)，前者在PCI 术前静脉滴注丹参注射液20 mL，1 次 /d，连续3 d；后者静脉滴注丹参多酚酸盐注射液200 mg，1 次/d，连续3 d。分别在PCI 术前及术后即刻检测冠状动脉血流储备 (CFR)、冠状动脉微循环阻力系数(IMR)及TIMI 血流分级。结果:两组术后CFR、IMR 及TIMI 血流分级均较术前明显改善(P＜ 0.05)，丹参多酚酸盐组IMR 明显小于丹参组(P＜0.05)，CFR、TIMI 血流分级与丹参组比较无统计学意义(P＞0.05)。结论:丹参注 射液与丹参多酚酸盐注射液均能显著改善UA 患者的冠状动脉微循环，丹参多酚酸盐注射液一定程度上优于丹参注射液。 [ABSTRACT FROM AUTHOR]