糖尿病肾病患者血清亲环素水平及其临床意义.

Objective: To investigate the level of serumcyclophilin A (CyPA) in diabetic nephropathy (DN) and its clinical significance. Methods: 86 cases of type 2 diabetic nephropathy (T2DN) in our hospital from October 2014 to October 2015 were divided into three groups according to the results of 24 h urinary albumin excretion rate(UAER), namely diabetes nephropathy group(SDMgroup) 30 cases and the early diabetic nephropathy group (EDN group) 28 cases, diabetic nephropathy group (CDN group) 28 cases. The other selected healthy physical examination in our hospital, 26 patients of control group (NC group) and compared between the 4 groups. The level of serum CyPA, systolic blood pressure(SBP), diastolic bloodpressure(DBP), Glycosylated hemoglobin(HbA1c), serum creatinine (Cr), blood urea nitrogen (BUN) level in the EDN group, in the conventional control of blood pressure, blood glucose, blood lipid on the basis of giving small doses of Tripterygium wilfordii tablets for 4 weeks. The analysis of correlation between CyPA level and 24 h UAER. Results: SDMgroup, EDN group, CDN group, HbAlc level was significantly higher than that of group CN(P<0.05). EDN group, CDN group of 24 h UAER was significantly higher than that of SDMgroup and CN group (P<0.05), CDN group of 24 h UAER was significantly higher than that of EDNgroup (P<0.05), while no significant group EDNand CNa group of 24 h UAER level difference(P>0.05) in. SDM group, EDN group, CDN group, CyPA group, the level of serum CN increased 22, there were significant differences(P<0.05). The serum CyPA level in patients with diabetic nephropathy was positively correlated with 24 h UAER (r=0.697, P<0.05). Conclusions: serumCyPA level can reflect the severity of renal injury in diabetic nephropathy patients. [ABSTRACT FROM AUTHOR]

目的：探讨糖尿病肾病(DN)患者血清亲环素A(CyPA)水平及其临床意义。方法：将我院2014 年10 月-2015 年10 月收治的 86 例2 型糖尿病肾病(T2DN)患者依据24 h尿白蛋白排泄率(UAER)水平分为3 组，即糖尿病无肾病组(SDM组) 30 例、早期糖尿 病肾病组(EDN 组)28 例、糖尿病肾病组(CDN 组)28 例。另选取同期本院健康体检者26 例为对照组(NC 组)。比较4 组的血清 CyPA水平、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c)、血肌酐(Cr)、尿素氮(BUN)水平。以EDN 组为实验组，在常规控制 血压、血糖、血脂等基础上，给予小剂量雷公藤多甙片治疗4 周，分析CyPA水平与24 h UAER的相关性。结果：SDM组、EDN组、 CDN 组的HbAlc 水平显著高于CN组(P<0.05)。EDN组、CDN 组的24 h UAER 水平显著高于SDM组和CN组(P<0.05)，CDN 组 的24 h UAER 水平显著高于EDN组(P<0.05)，而EDN 组和CN 组的24 h UAER 水平比较差异无统计学意义(P>0.05)。SDM组、 EDN组、CDN组、CN 组血清CyPA 水平依次升高，两两比较差异均有统计学意义(P<0.05)。糖尿病肾病患者血清CyPA 水平与 24 h UAER 呈正相关(r=0.697，P<0.05)。结论：血清CyPA水平在一定程度上能反映糖尿病肾病患者的肾损伤严重程度。 [ABSTRACT FROM AUTHOR]