Roles of CDKs in RNA polymerase II transcription of the HIV-1 genome.
In: Transcription (2154-1264), Jg. 10 (2019-04-01), Heft 2, S. 111-117
Online
academicJournal
Zugriff:
Studies of RNA Polymerase II (Pol II) transcription of the HIV-1 genome are of clinical interest, as the insight gained may lead to strategies to selectively reactivate latent viruses in patients in whom viral replication is suppressed by antiviral drugs. Such a targeted reactivation may contribute to a functional cure of infection. This review discusses five Cyclin-dependent kinases – CDK7, CDK9, CDK11, CDK2, and CDK8 – involved in transcription and processing of HIV-1 RNA. CDK7 is required for Pol II promoter clearance of reactivated viruses; CDK7 also functions as an activating kinase for CDK9 when resting CD4+ T cells harboring latent HIV-1 are activated. CDK9 is targeted by the viral Tat protein and is essential for productive Pol II elongation of the HIV-1 genome. CDK11 is associated with the TREX/THOC complex and it functions in the 3′ end processing and polyadenylation of HIV-1 transcripts. CDK2 phosphorylates Tat and CDK9 and this stimulates Tat activation of Pol II transcription. CDK8 may stimulate Pol II transcription of the HIV-1 genome through co-recruitment with NF-κB to the viral promoter. Some notable open questions are discussed concerning the roles of these CDKs in HIV-1 replication and viral latency. [ABSTRACT FROM AUTHOR]
Titel: |
Roles of CDKs in RNA polymerase II transcription of the HIV-1 genome.
|
---|---|
Autor/in / Beteiligte Person: | Rice, Andrew P. |
Link: | |
Zeitschrift: | Transcription (2154-1264), Jg. 10 (2019-04-01), Heft 2, S. 111-117 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 2154-1264 (print) |
DOI: | 10.1080/21541264.2018.1542254 |
Schlagwort: |
|
Sonstiges: |
|