Assessment of coronary flow reserve predicts long-term outcome of responders to cardiac resynchronization therapy.
In: Heart & Vessels, Jg. 34 (2019-05-01), Heft 5, S. 763-770
Online
academicJournal
Zugriff:
Cardiac resynchronization therapy (CRT) has been established as a treatment for patients with chronic heart failure (HF). We tested the hypothesis that assessment of coronary flow reserve (CFR) predicts the long-term outcome of CRT. The study consisted of 114 HF patients implanted with a CRT device for the treatment of advanced HF between April 2010 and April 2018. After excluding patients that withdrew from long-term follow-up and patients missing a baseline CFR measurement, we enrolled 53 eligible patients. CFR was determined non-invasively by transthoracic echocardiography. Based on the ROC curve for predicting the appearance of major adverse cerebral and cardiovascular events (MACCE), the level of preserved CFR was set at >1.35 in responders. Accurate follow-up information (mean 873 ± 498 days) was obtained in 23 patients with a preserved CFR (16 females; mean age 71 ± 7.9 years) and 11 patients with a depressed CFR (5 females; mean age, 73 ± 7.6 years) in responders. Kaplan–Meier survival analysis demonstrated that the depressed CFR group had a higher prevalence of MACCE than the preserved CFR group (log rank, 9.83; p = 0.0021). Multivariate analysis revealed that depressed CFR was associated with MACCE (hazard ratio 4.88, 95% confidence interval 1.13–26.5, p = 0.0329). Our results suggest that the assessment of CFR predicts the outcome in responders to CRT. Preservation of coronary circulation flow might underlie one of the mechanisms for a better response to CRT in responders. [ABSTRACT FROM AUTHOR]
Titel: |
Assessment of coronary flow reserve predicts long-term outcome of responders to cardiac resynchronization therapy.
|
---|---|
Autor/in / Beteiligte Person: | Yufu, Kunio ; Kondo, Hidekazu ; Shinohara, Tetsuji ; Ishii, Yumi ; Yoshimura, Seiichiro ; Abe, Ichitaro ; Saito, Shotaro ; Fukui, Akira ; Okada, Norihiro ; Akioka, Hidefumi ; Teshima, Yasushi ; Nakagawa, Mikiko ; Takahashi, Naohiko |
Link: | |
Zeitschrift: | Heart & Vessels, Jg. 34 (2019-05-01), Heft 5, S. 763-770 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 0910-8327 (print) |
DOI: | 10.1007/s00380-018-1308-0 |
Schlagwort: |
|
Sonstiges: |
|