Volltext verfügbar nach Anmeldung bzw. im Campus-Netz.
Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis.
In: PLoS ONE, Jg. 14 (2019-07-17), Heft 7, S. 1-10
Online
academicJournal
Zugriff:
Purpose: Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plasminogen activator inhibitor-1 expression (PAI-1) in endometriotic tissues is increased in women with DIE. Methods: In this blinded in vitro study, immunohistochemistry and Histoscore were used to examine the expression of PAI-1 in glandular epithelium (GECs) and stroma (SCs) in a total of 62 women: deep infiltrating uterosacral/rectovaginal endometriosis (DIE; n = 13), ovarian endometrioma (OMA; n = 14), superficial peritoneal uterosacral/cul-de-sac endometriosis (SUP; n = 23), uterine (eutopic) endometrium from women with endometriosis (UE; n = 6), and non-endometriosis eutopic endometrium (UC; n = 6). The following patient characteristics were also collected: age, American Fertility Society stage, hormonal suppression, phase of menstrual cycle, dysmenorrhea score and deep dyspareunia score. Results: PAI-1 expression in GECs and SCs of the DIE group was significantly higher than that of SUP group (p = 0.01, p = 0.01, respectively) and UE group (p = 0.03, p = 0.04, respectively). Interestingly, increased PAI-1 expression in GECs and SCs was also significantly correlated with increased dysmenorrhea (r = 0.38, p = 0.01; r = 0.34, p = 0.02, respectively). Conclusions: We found higher expression of PAI-1 in DIE, and an association between PAI-1 and worse dysmenorrhea. [ABSTRACT FROM AUTHOR]
Titel: |
Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis.
|
---|---|
Autor/in / Beteiligte Person: | Alotaibi, Fahad T. ; Peng, Bo ; Klausen, Christian ; Lee, Anna F. ; Abdelkareem, Amr O. ; Orr, Natasha L. ; Noga, Heather ; Bedaiwy, Mohamed A. ; Yong, Paul J. |
Link: | |
Zeitschrift: | PLoS ONE, Jg. 14 (2019-07-17), Heft 7, S. 1-10 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0219064 |
Schlagwort: |
|
Sonstiges: |
|