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Near-infrared autofluorescence in young choroideremia patients.
In: Ophthalmic Genetics, Jg. 40 (2019-10-01), Heft 5, S. 421-427
Online
academicJournal
Zugriff:
Purpose: To study near-infrared autofluorescence (NIR-AF) and short- wave autofluorescence (SW-AF) imaging modalities in young patients affected with choroideremia (CHM). Methods: NIR-AF and SW-AF images, Optical coherence tomography (OCT) and color fundus images were acquired from 3 young CHM patients (6 eyes) enrolled at the Regional Reference Center for Hereditary Retinal Degenerations of the Eye Clinic in Florence. Results: We studied 3 young CHM patients (6 eyes). The mean age of the patients was 17,3 years. Using NIR-AF, patient P1 was characterized by speckled hypo-autofluorescent areas at the posterior pole with a preserved central hyper-autofluorescence while patient P2 and P3 were characterized by a preserved NIR-AF signal only at the fovea. Using SW-AF, patient P1 was characterized by a normal macular autofluorescence and by a speckled FAF pattern involved the vascular arcades while patient P2 and P3 showed well-demarcated hypo-autofluorescence areas involving the posterior pole with a preserved macular autofluorescence. The differences between NIR-AF and SW-AF were more pronounced in advanced stages. In correspondence of preserved NIR-AF, the OCT examination showed regular and continuous outer retinal hyperreflective bands. We observed abnormal RPE/Bruch's membrane complex and EZ band externally to the NIR-AF signal area. Conclusions: NIR-AF imaging confirms an early RPE involvement allowing us to identify and to quantify the RPE pigment loss in choroideremia. For this reason, NIR-AF imaging can be useful for monitoring the progression of the disease and to study the effect of future treatments [ABSTRACT FROM AUTHOR]
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Near-infrared autofluorescence in young choroideremia patients.
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Autor/in / Beteiligte Person: | Mucciolo, Dario Pasquale ; Murro, Vittoria ; Giorgio, Dario ; Sodi, Andrea ; Passerini, Ilaria ; Virgili, Gianni ; Rizzo, Stanislao |
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Zeitschrift: | Ophthalmic Genetics, Jg. 40 (2019-10-01), Heft 5, S. 421-427 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 1381-6810 (print) |
DOI: | 10.1080/13816810.2019.1666881 |
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