Age-related changes in plasma coenzyme Q<subscript>10</subscript> concentrations and redox state in apparently healthy children and adults
In: Clinica Chimica Acta, Jg. 347 (2004-09-01), Heft 1/2, S. 139-144
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Zugriff:
Background: Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency states have been described, there is a need to establish normal ranges in healthy children. The objectives of this study are to determine if age-related differences in reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), and CoQ redox state exist in childhood, and to establish reference intervals for these analytes in healthy children. Methods: Apparently healthy children (n=68) were selected from individuals with no history of current acute illness, medically diagnosed disease, or current medication treatment. Self-reported healthy adults (n=106) were selected from the ongoing Princeton Follow-up Study in greater Cincinnati. Participants were assessed for lipid profiles, ubiquinol concentration, ubiquinone concentration, total CoQ concentration, and CoQ redox ratio. Results: Mean total CoQ and ubiquinol concentrations are similar in younger children (0.2–7.6 years) and adults (29–78 years); however, lipid-adjusted total CoQ concentrations are significantly increased in younger children. Also CoQ redox ratio is significantly increased in younger and older children compared with adults. Conclusions: Elevated CoQ and redox ratios in children may be an indication of oxidative stress effects, which are associated with early development of coronary heart disease. [Copyright &y& Elsevier]
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Age-related changes in plasma coenzyme Q<subscript>10</subscript> concentrations and redox state in apparently healthy children and adults
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Autor/in / Beteiligte Person: | Miles, Michael V. ; Horn, Paul S. ; Tang, Peter H. ; Morrison, John A. ; Miles, Lili ; DeGrauw, Ton ; Pesce, Amadeo J. |
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Zeitschrift: | Clinica Chimica Acta, Jg. 347 (2004-09-01), Heft 1/2, S. 139-144 |
Veröffentlichung: | 2004 |
Medientyp: | academicJournal |
ISSN: | 0009-8981 (print) |
DOI: | 10.1016/j.cccn.2004.04.003 |
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