Thirty years of CMV seroprevalence—a longitudinal analysis in a German university hospital.
In: European Journal of Clinical Microbiology & Infectious Diseases, Jg. 39 (2020-06-01), Heft 6, S. 1095-1102
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Zugriff:
Human cytomegalovirus (CMV) is a significant cause of morbidity and mortality in patient groups at risk. We have previously shown that the anti-CMV IgG seroprevalence in an urban region of Germany has changed over the last decades. Overall, a decline from 63.7 to 57.25% had been observed between 1988–1997 and 1998–2008 (p < 0,001). Here, we continuously follow the trends to the most recent decade 2009 to 2018. In a retrospective analysis, we determined the seroprevalence of CMV IgG antibodies in our patient cohort, stratified by gender and selected groups at risk (e.g., patients with HIV infection; women of childbearing age). The overall prevalence of anti-CMV IgG non-significantly declined further from 57.25% in 1998–2008 to 56.48% in 2009–2018 (p = 0.881). Looking at gender differences, overall CMV seroprevalence in males declined to 52.82% (from 55.54% in 1998–2008; p = 0.0254), while it non-significantly increased in females to 59.80%. The high seroprevalence in patients with a known HIV infection further increased from 87.46% in 1998–2008 to 92.93% in the current period (p = 0.9999). In women of childbearing age, no significant changes over the last three decades could be observed. The CMV seroprevalence in oncological patients was determined to be 60.64%. Overall, the former significant decline of CMV seroprevalence between the decades 1988–1997 and 1998–2008 in this urban region of Germany slowed down to a non-significant decrease of 0.77% (1998–2008 vs. 2009–2018). This might be an indicator that CMV seroprevalence has reached a plateau. [ABSTRACT FROM AUTHOR]
Titel: |
Thirty years of CMV seroprevalence—a longitudinal analysis in a German university hospital.
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Autor/in / Beteiligte Person: | Hoehl, Sebastian ; Berger, Annemarie ; Ciesek, Sandra ; Rabenau, Holger F. |
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Zeitschrift: | European Journal of Clinical Microbiology & Infectious Diseases, Jg. 39 (2020-06-01), Heft 6, S. 1095-1102 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0934-9723 (print) |
DOI: | 10.1007/s10096-020-03814-x |
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