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Synthesis of Polycyclic Spiro Pyrrolidone Derivatives via DBU‐Catalyzed Diastereoselective Vinylogous Aldol‐Michael Cascade Reaction.
In: ChemCatChem, Jg. 12 (2020-06-18), Heft 12, S. 3212-3215
Online
academicJournal
Zugriff:
A new DBU‐catalyzed vinylogous aldol‐Michael cascade strategy was developed for highly efficient construction of polycyclic heterocycles bearing a spiro pyrrolidone unit. Readily available o‐succinimide‐substituted benzaldehydes and 2(5H)‐furanone were utilized as bifunctional starting materials, both of which possess two potential reactive sites. Good to high yields were achieved under mild metal‐free conditions, along with the excellent diastereoselective generation of four adjacent stereogenic centers. This newly developed methodology provided an efficient and complementary synthetic approach to access spiro pyrrolidone derivatives. [ABSTRACT FROM AUTHOR]
Titel: |
Synthesis of Polycyclic Spiro Pyrrolidone Derivatives via DBU‐Catalyzed Diastereoselective Vinylogous Aldol‐Michael Cascade Reaction.
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Autor/in / Beteiligte Person: | Liu, Dandan ; Wang, Jiansheng ; Liu, Wenqin ; Zhang, Fang‐Lin ; Zhou, Yirong |
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Zeitschrift: | ChemCatChem, Jg. 12 (2020-06-18), Heft 12, S. 3212-3215 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1867-3880 (print) |
DOI: | 10.1002/cctc.202000463 |
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