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Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
In: Scientific Reports, Jg. 10 (2020-07-24), Heft 1, S. 1-12
Online
academicJournal
Zugriff:
The scavenger receptor CD163 is highly expressed in macrophages in sites of chronic inflammation where it has a not yet defined role. Here we have investigated development of collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) in CD163-deficient C57BL/6 mice. Compared to wild-type mice, the CIA in CD163-deficient mice had a several-fold higher arthritis score with early onset, prolonged disease and strongly enhanced progression. Further, the serum anti-collagen antibody isotypes as well as the cytokine profiles and T cell markers in the inflamed joints revealed that CD163-deficient mice after 52 days had a predominant Th2 response in opposition to a predominant Th1 response in CD163+/+ mice. Less difference in disease severity between the CD163+/+ and CD163−/− mice was seen in the CAIA model that to a large extent induces arthritis independently of T-cell response and endogenous Th1/Th2 balance. In conclusion, the present set of data points on a novel strong anti-inflammatory role of CD163. [ABSTRACT FROM AUTHOR]
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Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
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Autor/in / Beteiligte Person: | Svendsen, Pia ; Etzerodt, Anders ; Deleuran, Bent W. ; Moestrup, Søren K. |
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Zeitschrift: | Scientific Reports, Jg. 10 (2020-07-24), Heft 1, S. 1-12 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-020-69018-7 |
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