Decreased accuracy of the prostate cancer EAU risk group classification in the era of imaging-guided diagnostic pathway: proposal for a new classification based on MRI-targeted biopsies and early oncologic outcomes after surgery.
In: World Journal of Urology, Jg. 38 (2020-10-01), Heft 10, S. 2493-2500
Online
academicJournal
Zugriff:
Purpose: To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. Materials and methods: We included 1345 patients consecutively operated by radical prostatectomy (RP) since 2014, when MRI and TB were introduced in the diagnostic pathway. Patients underwent systematic biopsy (SB) only (n = 819) or SB and TB (n = 526) prior to RP during the same time period. Pathological and biochemical outcomes were compared between PCa men undergoing SB (SB cohort) and a combination of TB and SB (TB cohort). Kaplan–Meier and Cox regression models were used to assess biochemical recurrence-free survival (RFS). Results: Both cohorts were comparable regarding final pathology and RFS (p = 0.538). The EAU risk classification accurately predicted outcomes in SB cohort, but did not significantly separate low from intermediate risk in TB cohort (p = 0.791). In TB cohort, the new proposed three-group risk classification significantly improved the recurrence risk prediction compared with the EAU risk classification: HR 4 (versus HR 1.2, p = 0.009) for intermediate, and HR 15 (versus HR 6.5, p < 0.001) in high-risk groups, respectively. A fourth group defining very high-risk cases (≥ T2c clinical stage or grade group 5) was also proposed. Conclusions: The new classification integrating TB findings we propose meaningfully improves the recurrence prediction after surgery in patients undergoing a TB-based diagnostic pathway, compared with standard EAU risk classification which is still relevant for patients undergoing only SB. External validation is needed. [ABSTRACT FROM AUTHOR]
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Decreased accuracy of the prostate cancer EAU risk group classification in the era of imaging-guided diagnostic pathway: proposal for a new classification based on MRI-targeted biopsies and early oncologic outcomes after surgery.
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Autor/in / Beteiligte Person: | Ploussard, Guillaume ; Manceau, Cécile ; Beauval, Jean-Baptiste ; Lesourd, Marine ; Almeras, Christophe ; Gautier, Jean-Romain ; Loison, Guillaume ; Salin, Ambroise ; Soulié, Michel ; Tollon, Christophe ; Malavaud, Bernard ; Roumiguié, Mathieu |
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Zeitschrift: | World Journal of Urology, Jg. 38 (2020-10-01), Heft 10, S. 2493-2500 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0724-4983 (print) |
DOI: | 10.1007/s00345-019-03053-6 |
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