Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications.
In: Lab on a Chip, Jg. 20 (2020-10-07), Heft 19, S. 3591-3600
academicJournal
Zugriff:
Embolotherapy using particle embolics is normally performed with exogenous contrast to assist in visualization. However, the exact location of the embolics cannot be identified after contrast washout. We developed a novel, pseudo-check valve-integrated microfluidic device, that partitions barium- impregnated alginate from crosslinking solution, thereby preventing nozzle failure. This enables rapid and continuous generation of inherently X-ray-visible embolic microspheres (XEMs) with uniform size. The XEMs are visible under clinical X-ray and cone beam CT both in vitro and in vivo. In particular, we demonstrated the embolization properties of these XEMs in large animals, performing direct intra- and post-procedural assessment of embolic delivery. The persistent radiopacity of these XEMs enables real-time evaluation of embolization precision and offers great promise for non-invasive follow-up examination without exogenous contrast. We also demonstrated that bariatric arterial embolization with XEMs significantly suppresses weight gain in swine, as an example of a non-oncological application of embolotherapy. [ABSTRACT FROM AUTHOR]
Titel: |
Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications.
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Autor/in / Beteiligte Person: | Beh, Cyrus W. ; Fu, Yingli ; Weiss, Clifford R. ; Hu, Charles ; Arepally, Aravind ; Mao, Hai-Quan ; Wang, Tza-Huei ; Kraitchman, Dara L. |
Zeitschrift: | Lab on a Chip, Jg. 20 (2020-10-07), Heft 19, S. 3591-3600 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1473-0197 (print) |
DOI: | 10.1039/d0lc00098a |
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