Age-dependent Gender Differences in COVID-19 in Mainland China: Comparative Study.
In: Clinical Infectious Diseases, Jg. 71 (2020-11-01), Heft 9, S. 2488-2494
academicJournal
Zugriff:
Background The ongoing pandemic of novel coronavirus disease 2019 (COVID-19) is challenging the global public health system. Sex differences in infectious diseases are a common but neglected problem. Methods We used the national surveillance database of COVID-19 in mainland China to compare gender differences in attack rate (AR), proportion of severe and critical cases (PSCC), and case fatality rate (CFR) in relation to age, affected province, and onset-to-diagnosis interval. Results The overall AR was significantly higher in females than in males (63.9 vs 60.5 per 1 million persons; P ˂.001). In contrast, PSCC and CFR were significantly lower among females (16.9% and 4.0%) than among males (19.5% and 7.2%), with odds ratios of 0.87 and 0.57, respectively (both P ˂.001). The female-to-male differences were age dependent, and were significant among people aged 50–69 years for AR and in patients aged 30 years or older for both PSCC and CFR (all P ≤.001). The AR, PSCC, and CFR varied greatly from province to province. However, female-to-male differences in AR, PSCC, and CFR were significant in the epicenter, Hubei province, where 82.2% confirmed cases and 97.4% deaths occurred. After adjusting for age, affected province, and onset-to-diagnosis interval, the female-to-male difference in AR, PSCC, and CFR remained significant in multivariate logistic regression analyses. Conclusions We elucidate an age-dependent gender dimorphism for COVID-19, in which females have higher susceptibility but lower severity and fatality. Further epidemiological and biological investigations are required to better understand the sex-specific differences for effective interventions. [ABSTRACT FROM AUTHOR]
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Age-dependent Gender Differences in COVID-19 in Mainland China: Comparative Study.
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Autor/in / Beteiligte Person: | Qian, Jie ; Zhao, Lin ; Ye, Run-Ze ; Li, Xiu-Jun ; Liu, Yuan-Li |
Zeitschrift: | Clinical Infectious Diseases, Jg. 71 (2020-11-01), Heft 9, S. 2488-2494 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1058-4838 (print) |
DOI: | 10.1093/cid/ciaa683 |
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