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The diagnostic value of contrast-enhanced ultrasound (CEUS) for assessing hepatocellular carcinoma compared to histopathology; a retrospective single-center analysis of 119 patients<superscript>1</superscript>.
In: Clinical Hemorheology & Microcirculation, Jg. 76 (2020-12-01), Heft 4, S. 453-458
Online
academicJournal
Zugriff:
BACKGROUND: HCC as the 6th most common tumor entity with the fourth highest mortality and an increasing prevalence especially due to today's lifestyle acquires a high attention in the clinical setting. Beside CECT and CEMRI, CEUS depicts a dynamic, low-risk and radiation free imaging method that finds its use mainly in screening and active surveillance programs. PURPOSE: The aim of the retrospective study was to evaluate the diagnostic value of CEUS in correlation to pathologic findings. MATERIALS AND METHODS: Between 2004 and 2018 a total number of 119 patients were included in this retrospective single-center study. Every patient underwent CEUS in addition to a native B-mode and Color-Doppler scan. After given informed consent SonoVue® (Bracco, Milan, Italy), a second-generation blood-pool agent, was used as contrast medium. Every examination was performed and interpreted by a single experienced radiologist (EFSUMB level 3). A low mechanical index (MI) of <0,2 was chosen to obtain a good imaging quality. RESULTS: All 119 included patients received CEUS followed by a liver biopsy for inter-modality comparison. In correlation to the pathology results, CEUS showed a diagnostic sensitivity of 96,6%, a specificity of 63,9%, a PPV of 86,7% and a NPV of 88,5% by detecting liver lesions suspicious for HCC. According to the Cohen's Kappa coefficient (k = 0,659) CEUS shows a strong inter-modality agreement in comparison to the histopathological finding. CONCLUSION: With a high sensitivity and a strong cross-modality comparability to histopathology, the CEUS is highly effective in the detection of suspicious HCC lesions. [ABSTRACT FROM AUTHOR]
Titel: |
The diagnostic value of contrast-enhanced ultrasound (CEUS) for assessing hepatocellular carcinoma compared to histopathology; a retrospective single-center analysis of 119 patients<superscript>1</superscript>.
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Autor/in / Beteiligte Person: | Marschner, C.A. ; Zhang, L. ; Schwarze, V. ; Völckers, W. ; Froelich, M.F. ; von Münchhausen, N. ; Schnitzer, M.L. ; Geyer, T. ; Fabritius, M.P. ; Rübenthaler, J. ; Clevert, D. A. |
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Zeitschrift: | Clinical Hemorheology & Microcirculation, Jg. 76 (2020-12-01), Heft 4, S. 453-458 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1386-0291 (print) |
DOI: | 10.3233/CH-209221 |
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