Ultrasound-guided implantation of radioactive <superscript>125</superscript>I seed in radioiodine refractory differentiated thyroid carcinoma.
In: BMC Cancer, Jg. 21 (2021-07-20), Heft 1, S. 1-9
Online
academicJournal
Zugriff:
Background: Treatment for radioiodine refractory differentiated thyroid carcinoma (RR-DTC) is challenging. The purpose of this study was to assess the efficacy and safety of ultrasound-guided implantation of radioactive 125I-seed in radioiodine refractory differentiated thyroid carcinoma. Methods: Thirty-six cervical metastatic lymph nodes (CMLNs) diagnosed with RR-DTC from 18 patients were enrolled in this retrospective study. US and contrast-enhanced ultrasound (CEUS) examinations were performed before implantation. Follow-up comprised US, CEUS, thyroglobulin (Tg) level and routine hematology at 1-3, 6, 9 and 12 months and every 6 months thereafter. The volumes of the nodules were compared before implantation and at each follow-up point. The volume reduction rate (VRR) of nodules was also recorded. Results: The median volume of the nodules was 523 mm3 (148, 2010mm3) initially, which decreased significantly to 53mm3 (0, 286mm3) (P < 0.01) at the follow-up point of 24 months with a median VRR as 95% (86,100%). During the follow-up period (the range was 24-50 months), 25 (69%) nodules had VRR greater than 90%, of which 12 (33%) nodules had VVR ≈ 100% with unclear structures and only 125I seed images were visible in the US. At the last follow-up visit, the serum Tg level decreased from 57.0 (8.6, 114.8) ng/ml to 4.9 (0.7, 50.3) ng/ml, (P < 0.01). Conclusion: US-guided 125I seed implantation is safety and efficacy in treating RR- DTC. It could be an effective supplement for the comprehensive treatment of thyroid cancer. [ABSTRACT FROM AUTHOR]
Titel: |
Ultrasound-guided implantation of radioactive <superscript>125</superscript>I seed in radioiodine refractory differentiated thyroid carcinoma.
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Autor/in / Beteiligte Person: | Chen, Wei ; Luo, Yu kun ; Zhang, Ying ; Song, Qing ; Tang, Jie |
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Zeitschrift: | BMC Cancer, Jg. 21 (2021-07-20), Heft 1, S. 1-9 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1471-2407 (print) |
DOI: | 10.1186/s12885-021-08500-5 |
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