CMV-Specific Cell-Mediated Immunity Predicts a High Level of CMV Replication After Prophylaxis Withdrawal in Lung Transplant Recipients.
In: Journal of Infectious Diseases, Jg. 224 (2021-08-01), Heft 3, S. 526-531
academicJournal
Zugriff:
Monitoring cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) is useful in predicting late-onset CMV infection after solid organ transplantation, but few data have been reported after lung transplantation (LT). CMV CMI against 2 CMV antigens (IE-1, pp65) was evaluated in 60 seropositive LT at 6-month prophylaxis withdrawal. LT with late-onset CMV infection showed significantly lower (IE-1)CMV CMI than patients without (P = .045), and was more evident in patients developing high viral loads (P = .010). (IE-1)CMV CMI independently predicted high first late-onset viral replication (odds ratio, 4.358; 95% confidence interval, 1.043-18.215). CMV-specific CMI may be useful in CMV preventive strategies after LT. [ABSTRACT FROM AUTHOR]
Titel: |
CMV-Specific Cell-Mediated Immunity Predicts a High Level of CMV Replication After Prophylaxis Withdrawal in Lung Transplant Recipients.
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Autor/in / Beteiligte Person: | Donadeu, Laura ; Revilla-López, Eva ; Jarque, Marta ; Crespo, Elena ; Torija, Alba ; Bravo, Carles ; Arcos, Ibai Los ; Meneghini, Maria ; Favà, Alex ; Román, Antonio ; Monforte, Víctor ; Bestard, Oriol ; Los Arcos, Ibai |
Zeitschrift: | Journal of Infectious Diseases, Jg. 224 (2021-08-01), Heft 3, S. 526-531 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiaa727 |
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