The Early Life Course of Body Weight and Gene Expression Signatures for Disease.
In: American Journal of Epidemiology, Jg. 190 (2021-08-01), Heft 8, S. 1533-1540
Online
academicJournal
Zugriff:
We examined the way body-weight patterns through the first 4 decades of life relate to gene expression signatures of common forms of morbidity, including cardiovascular disease (CVD), type 2 diabetes (T2D), and inflammation. As part of wave V of the nationally representative National Longitudinal Study of Adolescent to Adult Health (1997–2018) in the United States, mRNA abundance data were collected from peripheral blood (n = 1,132). We used a Bayesian modeling strategy to examine the relative associations between body size at 5 life stages—birth, adolescence, early adulthood, young adulthood, and adulthood—and gene expression–based disease signatures. We compared life-course models that consider critical or sensitive periods, as well as accumulation over the entire period. Our results are consistent with a sensitive-period model when examining CVD and T2D gene expression signatures: Birth weight has a prominent role for the CVD and T2D signatures (explaining 33.1% and 22.1%, respectively, of the total association accounted for by body size), while the most recent adult obesity status (ages 33–39) is important for both of these gene expression signatures (24.3% and 35.1%, respectively). Body size in all life stages was associated with inflammation, consistent with the accumulation model. [ABSTRACT FROM AUTHOR]
Titel: |
The Early Life Course of Body Weight and Gene Expression Signatures for Disease.
|
---|---|
Autor/in / Beteiligte Person: | Potente, Cecilia ; Harris, Kathleen Mullan ; Chumbley, Justin ; Cole, Steven W ; Gaydosh, Lauren ; Xu, Wenjia ; Levitt, Brandt ; Shanahan, Michael J |
Link: | |
Zeitschrift: | American Journal of Epidemiology, Jg. 190 (2021-08-01), Heft 8, S. 1533-1540 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0002-9262 (print) |
DOI: | 10.1093/aje/kwab049 |
Schlagwort: |
|
Sonstiges: |
|