Long-term results of hypofractionation with concomitant boost in patients with early breast cancer: A prospective study.
In: PLoS ONE, Jg. 16 (2021-10-07), Heft 10, S. 1-11
Online
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Zugriff:
Aim: To report the long-term local control and survival of patients with early breast cancer who had hypofractionated whole breast irradiation with concomitant boost (Hypo-CB). Methods and materials: Between October 2009 and June 2010, 73 patients with early breast cancer (T1-3N0-1M0) who underwent breast conserving surgery were enrolled into the study. Thirty-six of these participants received 50 Gy of conventional irradiation in 25 fractions over 5 weeks to the whole breast with a sequential boost to the tumor bed with 10–16 Gy in 5–8 fractions (Conv-SEQ). The other 37 participants received a hypofractionated dose of 43.2 Gy in 16 fractions with an additional daily concomitant boost (CB) of 0.6 Gy over 3 weeks (Hypo-CB). Results: At a median follow-up time of 123 months, ipsilateral local recurrence (ILR) was found in 3 participants, 1 of whom was in the hypofractionated group. All 3 ILR were true local recurrence (TR). There were no significant differences in the 10-year disease free survival (DFS) and 10-year overall survival rates (OS) between the conventional and hypofractionated groups (93.9% vs. 94.4%, p = 0.96 and 91.9% vs. 91.6%, p = 0.792, respectively). Conclusion: This study showed that the effectiveness, DFS and OS were comparable between hypofractionated whole breast irradiation with a CB and the conventional irradiation with a sequential boost. [ABSTRACT FROM AUTHOR]
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Long-term results of hypofractionation with concomitant boost in patients with early breast cancer: A prospective study.
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Autor/in / Beteiligte Person: | Saksornchai, Kitwadee ; Jaruthien, Thitiporn ; Nantavithya, Chonnipa ; Shotelersuk, Kanjana ; Rojpornpradit, Prayuth |
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Zeitschrift: | PLoS ONE, Jg. 16 (2021-10-07), Heft 10, S. 1-11 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0258186 |
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