1328: TIMP2 ATTENUATES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED ACUTE KIDNEY INJURY.
In: Critical Care Medicine, Jg. 50 (2022-01-02), S. 665-665
Online
academicJournal
Zugriff:
TIMP2 SP -/- sp mice's kidney tissues exhibited more than those of WT mice evidenced by H&E staining, respectively. The renal tubular-specific TIMP2-knockout mice after cecum ligation and puncture (CLP) and LPS treatment showed upregulated cellular inflammasome response when compared with the wildtype (WT) mice, which indicated that TIMP2 is an endogenous regulator of inflammasome activation as a potential target for the treatment of NLRP3 inflammasome-driven AKI. B Results: b TIMP2 SP -/- sp mice exhibited more severe kidney injury compared to WT after CLP and LPS treatment. [Extracted from the article]
Titel: |
1328: TIMP2 ATTENUATES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED ACUTE KIDNEY INJURY.
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Autor/in / Beteiligte Person: | Xu, Dongxue |
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Zeitschrift: | Critical Care Medicine, Jg. 50 (2022-01-02), S. 665-665 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0090-3493 (print) |
DOI: | 10.1097/01.ccm.0000811636.29620.d1 |
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