Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes.
In: eLife, 2022-01-27, S. 1-32
Online
academicJournal
Zugriff:
Y chromosomes across diverse species convergently evolve a gene-poor, heterochromatic organization enriched for duplicated genes, LTR retrotransposons, and satellite DNA. Sexual antagonism and a loss of recombination play major roles in the degeneration of young Y chromosomes. However, the processes shaping the evolution of mature, already degenerated Y chromosomes are less well-understood. Because Y chromosomes evolve rapidly, comparisons between closely related species are particularly useful. We generated de novo long-read assemblies complemented with cytological validation to reveal Y chromosome organization in three closely related species of the Drosophila simulans complex, which diverged only 250,000 years ago and share >98% sequence identity. We find these Y chromosomes are divergent in their organization and repetitive DNA composition and discover new Y-linked gene families whose evolution is driven by both positive selection and gene conversion. These Y chromosomes are also enriched for large deletions, suggesting that the repair of double-strand breaks on Y chromosomes may be biased toward microhomology-mediated end joining over canonical non-homologous end-joining. We propose that this repair mechanism contributes to the convergent evolution of Y chromosome organization across organisms. [ABSTRACT FROM AUTHOR]
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Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes.
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Autor/in / Beteiligte Person: | Chang, Ching-Ho ; Gregory, Lauren E. ; Gordon, Kathleen E. ; Meiklejohn, Colin D. ; Larracuente, Amanda M. |
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Zeitschrift: | eLife, 2022-01-27, S. 1-32 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 2050-084X (print) |
DOI: | 10.7554/eLife.75795 |
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