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Ursodeoxycholic acid markedly promotes the absorption of microemulsion‐formulated cyclosporine A: A case report.
In: Journal of Clinical Pharmacy & Therapeutics, Jg. 47 (2022-02-01), Heft 2, S. 260-262
Online
academicJournal
Zugriff:
What is known and objective: Cyclosporine A (CyA) causes intrahepatic biliary stasis via inhibition of bile acid excretion through the bile salt export pump. We report a case of a patient in whom ursodeoxycholic acid (UDCA) markedly promoted the absorption of microemulsion‐formulated CyA. Case summary: The patient was a 22‐year‐old Japanese man diagnosed with stage 3 aplastic anaemia. He was treated with CyA, and 2 h post‐dose (C2) was increased by UDCA. What is new and conclusion: A remarkable interaction was observed between CyA and UDCA. This is a valuable finding for improving the treatment strategies for haematological disorders. [ABSTRACT FROM AUTHOR]
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Ursodeoxycholic acid markedly promotes the absorption of microemulsion‐formulated cyclosporine A: A case report.
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Autor/in / Beteiligte Person: | Takeshima, Hidemi ; Yoshikawa, Naoki ; Akizuki, Keiichi ; Hidaka, Tomonori ; Shimoda, Kazuya ; Ikeda, Ryuji |
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Zeitschrift: | Journal of Clinical Pharmacy & Therapeutics, Jg. 47 (2022-02-01), Heft 2, S. 260-262 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0269-4727 (print) |
DOI: | 10.1111/jcpt.13496 |
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