The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases.
In: Virology, Jg. 569 (2022-04-01), S. 37-43
Online
academicJournal
Zugriff:
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL: 3∙108 copies/mL; p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic. • SARS-CoV-2 viral loads drop fast within one week of symptom onset. • Positive viral culture results have high viral loads and low symptom to test time. • Maximum viral loads positively correlate with the magnitude of Ro-N-Ig assay. • Maximum viral loads significantly differ between WHO groups. [ABSTRACT FROM AUTHOR]
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The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases.
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Autor/in / Beteiligte Person: | Puchinger, Kerstin ; Castelletti, Noemi ; Rubio-Acero, Raquel ; Geldmacher, Christof ; Eser, Tabea M. ; Deák, Flora ; Paunovic, Ivana ; Bakuli, Abhishek ; Saathoff, Elmar ; von Meyer, Alexander ; Markgraf, Alisa ; Falk, Philine ; Reich, Jakob ; Riess, Friedrich ; Girl, Philipp ; Müller, Katharina ; Radon, Katja ; Guggenbuehl Noller, Jessica Michelle ; Wölfel, Roman ; Hoelscher, Michael |
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Zeitschrift: | Virology, Jg. 569 (2022-04-01), S. 37-43 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0042-6822 (print) |
DOI: | 10.1016/j.virol.2022.02.002 |
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