An assessment of liver lesions using a combination of CEUS LI-RADS and AFP.
In: Abdominal Radiology, Jg. 47 (2022-04-01), Heft 4, S. 1311-1320
Online
academicJournal
Zugriff:
Purpose: To improve noninvasive diagnosis of HCC using a combination of CE US LI-RADS and alpha-fetoprotein (AFP). Methods: 757 solitary liver nodules from 757 patients at risk of HCC with CE US and serum AFP test were categorized as LR-1 to LR-5 through LR-M according to CE US LI-RADS version 2017. In LR-3, LR-4, and LR-M nodules, those with AFP > 200 ng/ml were reclassified as mLR-5. Nodules with LR-5 and mLR-5 were reclassified as definitely HCC to modify CE US LI-RADS. Diagnostic performance was assessed with specificity, sensitivity, and PPV. Results: The sensitivity, specificity, and PPV of LR-5 as a predictor of HCC were 64.7%, 97.8%, and 98.9%, respectively. 32.1% patients with solitary liver nodule had AFP greater than 200 ng/ml, of which 98.8% were HCC (25.8%, 7.5%, 2.5% assigned to LR-M, LR-4, LR-3, respectively) and 1.2% were Combined Hepatocellular Cholangiocarcinoma. After modification, the sensitivity increased to 79.6% (P < 0.001), while specificity and PPV remained high (96.6% and 98.7%, P > 0.050). Conclusion: The combination of CE US LI-RADS and AFP for diagnosing HCC improved diagnostic sensitivity significantly, while maintaining high PPV and specificity in patients with the solitary liver nodule. [ABSTRACT FROM AUTHOR]
Titel: |
An assessment of liver lesions using a combination of CEUS LI-RADS and AFP.
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Autor/in / Beteiligte Person: | Li, Chao-qun ; Huang, Hui ; Ruan, Si-min ; Hu, Hang-tong ; Xian, Meng-fei ; Xie, Xiao-yan ; Lu, Ming-de ; Kuang, Ming ; Wang, Ying ; Chen, Li-da |
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Zeitschrift: | Abdominal Radiology, Jg. 47 (2022-04-01), Heft 4, S. 1311-1320 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 2366-004X (print) |
DOI: | 10.1007/s00261-022-03428-1 |
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