The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women.

Background/Aim. Skeletal muscles and bones are essential tissues that, in addition to supporting the body, are the primary site of postprandial glucose intake, which is significantly associated with insulin resistance. The aim of this study was to determine the effect of insulin resistance on bone mineral density (BMD) and fracture risk and re-evaluate the relationship between muscle properties and BMD and insulin resistance in postmenopausal women in Serbia. Methods. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was calculated in postmenopausal women who were divided into two groups. The "cut-off" value of insulin resistance for the group with "Low HOMAIR" was < 2, and for "High HOMA-IR" > 2. Fat mass (FM), lean mass (LM), and BMD were measured on the hip and spine using a densitometer with dual-energy X-ray absorptiometry. Results. FM and LM had an evident impact on BMD. The decrease in LM and fat buildup was associated with a higher incidence of insulin resistance. A positive correlation was confirmed between HOMA-IR and BMD on the spine and hip, but there was no correlation between insulin resistance and fracture risk. Conclusion. LM and FM have significant effects on BMD. The association between LM, FM, BMD and the onset of insulin resistance in postmenopausal women is confirmed. However, women with higher insulin resistance levels and higher BMD do not have a lower fracture risk. [ABSTRACT FROM AUTHOR]

Uvod/Cilj. Skeletni mišići i kosti su važna tkiva koja, osim uloge u držanju tela, predstavljaju i primarno mesto preuzimanja glukoze nakon obroka, što je značajno povezano sa rezistencijom na insulin. Cilj rada bio je da se utvrdi uticaj insulinske rezistencije na mineralnu gustinu kosti (MGK) i rizik od nastanka preloma, kao i da se ispita veza između karakteristika mišića i MGK i insulinske rezistencije kod žena u postmenopauzi u Srbiji. Metode. Homeostatski model - rezistencija na insulin (HOMA-IR), izračunat je kod žena u postmenopauzi koje su bile podeljene u dve grupe. Granične vrednosti (cut-off) insulinske rezistencije za grupu sa „niskim HOMA-IR" bila je < 2, a z a g rupu s a „ visokim H OMA-IR" > 2. Masno tkivo (MT), bezmasno tkivo (BT) i MGK mereni su na kuku i kičmenom stubu pomoću denzitometra sa dvoenergetskom X-zračnom apsorpciometrijom. Rezultati. MT i BT su imali očigledan uticaj na MGK. Smanjenje BT i nakupljanje masti bilo je povezano sa višom učestalošću nastanka rezistencije na insulin. Primećena je pozitivna korelacija između HOMA-IR i MGK na kičmi i kuku, ali nije postojala korelacija između insulinske rezistencije i rizika od nastanka preloma. Zaključak. MT i BT imaju značajan uticaj na MGK. Potvrđena je povezanost između MT, BT, MGK i nastanka insulinske rezistencije kod žena u postmenopauzi. Međutim, žene sa višim nivoom insulinske rezistencije i većim MGK nemaju niži rizik od nastanka preloma. [ABSTRACT FROM AUTHOR]