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Cardiometabolic Health After Pediatric Cancer Treatment: Adolescents Are More Affected than Children.
In: Nutrition & Cancer, Jg. 74 (2022-10-01), Heft 9, S. 3236-3252
Online
academicJournal
Zugriff:
This cross-sectional study aimed at comparing the cardiometabolic (CM) health of children and adolescents and identifying factors associated with CM complications shortly after cancer treatment. Cancer-related characteristics, blood pressure (BP), anthropometry, and biochemical parameters were collected in 80 patients (56.3% female, mean age: 11.8 years; range: 4.5 − 21.0) a mean of 1.4 years following therapy completion. Compared to children, adolescents had higher mean z-score of insulin (–0.47 vs. 0.20; P = 0.01), HOMA-IR (–0.40 vs. 0.25; P = 0.02), waist-to-height ratio (0.36 vs. 0.84; P = 0.01), subscapular skinfold thickness (–0.19 vs. 0.47; P = 0.02), total body fat (–1.43 vs. 0.26; P < 0.01), and lower mean z-score of HDL-C (0.07 vs. –0.53; P < 0.01). Adolescents were more likely to have high BP (42% vs. 15%; P < 0.01), dyslipidemia (64% vs. 15%; P < 0.001), and cumulating ≥ 2 CM complications (42% vs. 2%; P < 0.001) than children. Adiposity indices (z-scores) were associated with high BP [odds ratio (OR) ranging from 2.11 to 4.09] and dyslipidemia (OR ranging from 2.06 to 4.34). These results suggest that adolescents have a worse CM profile than children shortly after therapy and that adiposity parameters are associated with CM complications, highliting the importance to develop intervention strategies targeting this population. [ABSTRACT FROM AUTHOR]
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Cardiometabolic Health After Pediatric Cancer Treatment: Adolescents Are More Affected than Children.
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Autor/in / Beteiligte Person: | Bélanger, Véronique ; Napartuk, Mélanie ; Bouchard, Isabelle ; Meloche, Caroline ; Curnier, Daniel ; Sultan, Serge ; Laverdière, Caroline ; Sinnett, Daniel ; Marcil, Valérie |
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Zeitschrift: | Nutrition & Cancer, Jg. 74 (2022-10-01), Heft 9, S. 3236-3252 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0163-5581 (print) |
DOI: | 10.1080/01635581.2022.2072908 |
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