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Nintedanib-Induced Delayed Mucosal Healing after Adjuvant Radiation in a Case of Oropharyngeal Carcinoma.
In: Case Reports in Oncology, Jg. 15 (2022-05-01), Heft 2, S. 776-782
Online
academicJournal
Zugriff:
Since the launch of imatinib in 2001, tyrosine kinase inhibitors are being used in chemotherapy for a wide range of malignant tumors. Drugs that inactivate multiple molecular mechanisms are called multikinase inhibitors (MKIs). Nintedanib is a type of MKI that inhibits downstream cascades in three systems: vascular endothelial growth factor receptor, fibroblast growth factor receptor, and platelet-derived growth factor receptor inhibitions. It was initially developed as an anticancer drug for non-small-cell lung carcinoma; however, it was also found to inhibit the proliferation of fibroblasts associated with chronic inflammation in the lungs. Therefore, it is being more widely used to treat idiopathic pulmonary fibrosis, a benign disease, than as an antineoplastic agent. Several studies have reported adverse events associated with the concurrent use of MKIs with surgery or radiotherapy. Specifically, there has been a report cautioning against delayed wound healing associated with the use of nintedanib in patients undergoing surgery. However, there is no specific mention of its concurrent use during irradiation. We describe a case of a 72-year-old man with severely delayed recovery from radiation mucositis when nintedanib was being administered for benign disease. [ABSTRACT FROM AUTHOR]
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Nintedanib-Induced Delayed Mucosal Healing after Adjuvant Radiation in a Case of Oropharyngeal Carcinoma.
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Autor/in / Beteiligte Person: | Takahashi, Satoru ; Endo, Masashi ; Fukuda, Yukiko ; Ogawa, Kazunari ; Nakamura, Michiko ; Okada, Kohei ; Kawahara, Masahiro ; Akahane, Keiko ; Nagatomo, Takafumi ; Onaga, Ryutaro ; Nishino, Hiroshi ; Mori, Harushi ; Shirai, Katsuyuki |
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Zeitschrift: | Case Reports in Oncology, Jg. 15 (2022-05-01), Heft 2, S. 776-782 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1662-6575 (print) |
DOI: | 10.1159/000526077 |
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