The polysaccharides from the fruits of Lycium barbarum L. modify the gut community profile and alleviate dextran sulfate sodium-induced colitis in mice.
In: International Journal of Biological Macromolecules, Jg. 222 (2022-12-10), S. 2244-2257
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Zugriff:
In the present study, the effects of a purified fraction of polysaccharides from the fruits of Lycium barbarum L. (LBPs), named LBPs-4, on the dextran sodium sulfate (DSS)-induced colitis in mice were evaluated. The results showed that LBPs-4 decreased disease activity index score, prevented colon shortening and reduced plasma levels of pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1) and prostaglandin E2) in mice with colitis. LBPs-4 could increase the relative abundances of Akkermansia and Bifidobacterium in gut microbiota, and it also mitigated the intestinal barrier damage by upregulating the level of tight junction protein ZO-1 and the number of goblet cells in colon. Moreover, the results of in vitro culture indicated that the growth of Bifidobacterium longum subsp. infantis CCX 19042 was promoted by LBPs-4, whereas the culture media of LBPs-4 by Bacteroides ovatus with or without addition of mucin could enhance the growth of Akkermansia muciniphila. Collectively, these results suggested that LBPs-4 should be potential prebiotics for the treatment of colitis. [ABSTRACT FROM AUTHOR]
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The polysaccharides from the fruits of Lycium barbarum L. modify the gut community profile and alleviate dextran sulfate sodium-induced colitis in mice.
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Autor/in / Beteiligte Person: | Zhou, Wangting ; Kan, Xuhui ; Chen, Guijie ; Sun, Yi ; Ran, Linwu ; Yan, Yamei ; Mi, Jia ; Lu, Lu ; Zeng, Xiaoxiong ; Cao, Youlong |
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Zeitschrift: | International Journal of Biological Macromolecules, Jg. 222 (2022-12-10), S. 2244-2257 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0141-8130 (print) |
DOI: | 10.1016/j.ijbiomac.2022.10.015 |
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