芪明颗粒联合玻璃酸钠滴眼液治疗儿童中度干眼症的疗效 及对泪液氧化应激和炎症因子的影响.
In: Progress in Modern Biomedicine, Jg. 23 (2023), Heft 1, S. 168-172
Online
academicJournal
Zugriff:
Objective: To investigate the efficacy of Qiming granule combined with sodium hyaluronate eye drops in the treatment of moderate dry eye in children and its effects on tear oxidative stress and inflammatory factors. Methods: A total of 90 patients with dry eye who came to Guiyang Maternal and Child Health Hospital from August 2019 to December 2021 were selected. The selected children were divided into control group (sodium hyaluronate eye drops treatment) and observation group (Qiming granule combined with sodium hyaluronate eye drops treatment) according to random number table method, with 45 cases in each group. Both groups were treated for 3months. The efficacy, clinical indexes, tear oxidative stress indexes, inflammatory factor indexes and adverse reactions were compared between the two groups. Results: The total clinical effective rate of 93.33% in the observation group was higher than 68.89% in the control group, the difference was statistically significant (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). 3 months after treatment, the tear film break-up time (BUT) and Schirmer I test (SIT) in the observation group were higher than those in the control group, and the corneal fluorescence staining (FL) score was lower than that in the control group (P<0.05).3 months after treatment, superoxide dismutase (SOD) in the observation group was higher than that in the control group, while malondialdehyde (MDA) and lipid peroxide (LPO) were lower than those in the control group (P<0.05). Interleukin 1β (IL-1 β), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP) and interleukin-8 (IL-8) in the observation group were lower than those in the control group 3 months after treatment (P<0.05). Conclusion: Children with moderate dry eye are treated with sodium hyaluronate eye drops combined with Qiming granule, it can effectively reduce the oxidative stress and inflammatory reaction in children, and it is safe. [ABSTRACT FROM AUTHOR]
目的:探讨芪明颗粒联合玻璃酸钠滴眼液治疗儿童中度干眼症的疗效及对泪液氧化应激和炎症因子的影响. 方法:选取 2019 年 8 月 ~2021 年 12 月期间来贵阳市妇幼保健院就诊的干眼症患儿, 共计 90 例. 入选的患儿根据随机数字表法分为对照组 (玻璃酸钠滴眼液治疗)和观察组 (芪明颗粒联合玻璃酸钠滴眼液治疗), 各为 45 例, 两组均治疗 3 个月. 对比两组疗效、临床指 标、泪液氧化应激指标、炎症因子指标和不良反应. 结果:观察组 93.33%的临床总有效率较对照组 68.89%高, 差异有统计学意义 (P<0.05). 两组不良反应发生率对比无差异 (P>0.05). 观察组治疗 3 个月后泪膜破裂时间 (BUT), 泪液分泌试验 (SIT)较对照组 高, 角膜荧光染色 (FL)评分较对照组低 (P<0.05). 观察组治疗 3 个月后超氧化物歧化酶 (SOD)高于对照组, 丙二醛 (MDA), 过氧 化脂质 (LPO)低于对照组 (P<0.05). 观察组治疗 3 个月后白细胞介素 1茁 (IL-1茁), 白介素 -6 (IL-6), 超敏 C 反应蛋白 (hs-CRP), 白 介素 -8 (IL-8)低于对照组 (P<0.05). 结论:儿童中度干眼症采用玻璃酸钠滴眼液联合芪明颗粒治疗, 可有效降低患儿的氧化应激 和炎症反应, 且安全性较好. [ABSTRACT FROM AUTHOR]
Titel: |
芪明颗粒联合玻璃酸钠滴眼液治疗儿童中度干眼症的疗效 及对泪液氧化应激和炎症因子的影响.
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Autor/in / Beteiligte Person: | 梁金才 ; 李秉倩 ; 朱健华 ; 林宇驰 ; 平, 蒋 |
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Zeitschrift: | Progress in Modern Biomedicine, Jg. 23 (2023), Heft 1, S. 168-172 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1673-6273 (print) |
DOI: | 10.13241/j.cnki.pmb.2023.01.033 |
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