血必凈注射液對重癥急性胰腺炎患者腎功能、炎性因子和外周血單核細胞TLR4/NF-κB信號通路.

Objective: To investigate the effects of Xuebijing injection on renal function, inflammatory factors and peripheral blood mononuclear cells toll like receptor 4 (TLR4) /NF-κB signaling pathway in patients with severe acute pancreatitis (SAP). Methods: Using the random number table method, 108 patients with severe SAP who were admitted to Suqian First People’s Hospital Affiliated to Nanjing Medical University from April 2019 to December 2021 were divided into control group (conventional treatment, n=54) and observation group (n=54, control group combined with Xuebijing injection). The changes situation of renal function, inflammatory factors and peripheral blood mononuclear cells TLR4/NF-κB signaling pathway were compared in two groups. The efficacy, improvement of clinical symptoms and occurrence of adverse reactions in two groups were observed at the same time. Results: The total effective rate in observation group was higher than that in control group (P<0.05). There was no difference in the adverse reaction rate in two groups (P>0.05). Compared with the control group, the relief time of abdominal distension and pain, the time of body temperature returning to normal, the disappearance time of nausea and vomiting and the length of hospital stay in observation group were shorter (P<0.05). Urea nitrogen (BUN) and serum creatinine (Scr) in two groups at 7d after treatment decreased (P<0.05), and BUN and Scr in observation group at 7 d after treatment were lower than those in control group (P<0.05). 7 d after treatment, interleukin-6 (IL-6),interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in two groups decreased (P<0.05), and 7 d after treatment, the IL-6, TNF-α and IL-1 in observation group were lower than those in control group (P<0.05). 7 d after treatment, TLR4 and NF-κB in two groups decreased (P<0.05), and 7 d after treatment, TLR4 and NF-κB in observation group were lower than those in control group (P<0.05). Conclusion: Xuebijing injection can effectively control the level of inflammatory factors in patients with severe SAP, reduce the damage of renal function, and which may be regulate the peripheral blood mononuclear cells TLR4/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

目的: 探討血必凈注射液對重癥急性胰腺炎 (SAP) 患者腎功能、炎性因子和外周血單核細胞Toll樣受體4 (TLR4) /NF-κB信號通路的影響. 方法: 采用隨機數字表法, 將南京醫科大學附屬宿遷第一人民醫院于2019年4月～2021年12月期間收治的重癥SAP患者108例分為對照組 (常規治療, n=54) 和觀察組 (n=54, 對照組基礎上結合血必凈注射液). 對比兩組腎功能、炎性因子和外周血單核細胞TLR4/NF-κB信號通路相關指標的變化情況. 同時觀察兩組療效、臨床癥狀改善情況和不良反應發生情況. 結果: 觀察組臨床總有效率較對照組高 (P<0.05). 兩組不良反應率比較無差異 (P>0.05) . 與對照組比較, 觀察組腹脹腹痛緩解時間、體溫恢復正常時間、惡心嘔吐消失時間、住院時間更短 (P<0.05). 兩組治療7 d后尿素氮 (BUN)、血肌酐 (Scr) 下降 (P<0.05), 觀察組治療7 d后BUN、Scr低于對照組 (P<0.05). 兩組治療7 d后白介素-6 (IL-6)、白介素-1 (IL-1)、腫瘤壞死因子-α (TNF-α) 下降 (P<0.05), 治療7 d后觀察組IL-6、TNF-α、IL-1較對照組低 (P<0.05). 兩組治療7 d后TLR4、NF-κB下降 (P<0.05), 觀察組治療7 d后TLR4、NF-κB低于對照組 (P<0.05). 結論: 血必凈注射液可有效控制重癥SAP患者炎性因子水平, 減輕腎功能損傷, 可能與調節外周血單核細胞TLR4/NF-κB信號通路有關. [ABSTRACT FROM AUTHOR]