Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson's Disease.
In: Cellular & Molecular Neurobiology, Jg. 43 (2023-07-01), Heft 5, S. 2377-2384
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Zugriff:
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson's disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD. [ABSTRACT FROM AUTHOR]
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Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson's Disease.
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Autor/in / Beteiligte Person: | Rees, Daniel ; Beynon, Amy L. ; Lelos, Mariah J. ; Smith, Gaynor A. ; Roberts, Luke D. ; Phelps, Lyndsey ; Dunnett, Stephen B. ; Morgan, Alwena H. ; Brown, Rowan M. ; Wells, Timothy ; Davies, Jeffrey S. |
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Zeitschrift: | Cellular & Molecular Neurobiology, Jg. 43 (2023-07-01), Heft 5, S. 2377-2384 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0272-4340 (print) |
DOI: | 10.1007/s10571-022-01282-9 |
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